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          Institute: MPI für medizinische Forschung     Collection: Abteilung Biomedizinische Optik     Display Documents



ID: 546038.0, MPI für medizinische Forschung / Abteilung Biomedizinische Optik
Number and Laminar Distribution of Neurons in a Thalamocortical Projection Column of Rat Vibrissal Cortex
Translation of Title:Number and Laminar Distribution of Neurons in a Thalamocortical Projection Column of Rat Vibrissal Cortex
Authors:Meyer, Hanno−Sebastian; Wimmer, Verena C.; Oberlaender, Marcel; de Kock, Christiaan; Sakmann, Bert; Helmstaedter, Moritz
Language:English
Date of Publication (YYYY-MM-DD):2010-06-09
Title of Journal:Cerebral Cortex
Journal Abbrev.:Cereb. Cortex
Volume:20
Issue / Number:10
Start Page:2277
End Page:2286
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:This is the second article in a series of three studies that investigate the anatomical determinants of thalamocortical (TC) input to excitatory neurons in a cortical column of rat primary somatosensory cortex (S1). Here, we report the number and distribution of NeuN−positive neurons within the C2, D2, and D3 TC projection columns in P27 rat somatosensory barrel cortex based on an exhaustive identification of 89 834 somata in a 1.15 mm3 volume of cortex. A single column contained 19 109 ± 444 neurons (17 560 ± 399 when normalized to a standard−size projection column). Neuron density differences along the vertical column axis delineated "cytoarchitectonic" layers. The resulting neuron numbers per layer in the average column were 63 ± 10 (L1), 2039 ± 524 (L2), 3735 ± 905 (L3), 4447 ± 439 (L4), 1737 ± 251 (L5A), 2235 ± 99 (L5B), 3786 ± 168 (L6A), and 1066 ± 170 (L6B). These data were then used to derive the layer−specific action potential (AP) output of a projection column. The estimates confirmed previous reports suggesting that the ensembles of spiny L4 and thick−tufted pyramidal neurons emit the major fraction of APs of a column. The number of APs evoked in a column by a sensory stimulus (principal whisker deflection) was estimated as 4441 within 100 ms post−stimulus.
Free Keywords:cortex layer; neuron density; POm; somatosensory barrel cortex; VPM
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie
MPI für medizinische Forschung/Abteilung Biomedizinische Optik
MPI für medizinische Forschung/Nachwuchsgruppe Neurophysiologie des Verhaltens
Identifiers:LOCALID:7665
URI:http%3A%2F%2Fcercor.oxfordjournals.org%2Fcontent%2...
URI:http%3A%2F%2Fcercor.oxfordjournals.org%2Fcontent%2...
URI:http%3A%2F%2Fcercor.oxfordjournals.org%2Fcontent%2...
DOI:10.1093%2Fcercor%2Fbhq067
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