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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2010-arch     Display Documents



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ID: 546558.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2010-arch
Subcellular targeting strategies for drug design and delivery.
Authors:Rajendran, Lawrence; Knölker, Hans-Joachim; Simons, Kai
Date of Publication (YYYY-MM-DD):2010
Title of Journal:Nature Reviews. Drug Discovery
Volume:9
Issue / Number:1
Start Page:29
End Page:42
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Many drug targets are localized to particular subcellular compartments, yet current drug design strategies are focused on bioavailability and tissue targeting and rarely address drug delivery to specific intracellular compartments. Insights into how the cell traffics its constituents to these different cellular locations could improve drug design. In this Review, we explore the fundamentals of membrane trafficking and subcellular organization, as well as strategies used by pathogens to appropriate these mechanisms and the implications for drug design and delivery.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:nn
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:1373
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