Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2010-arch     Display Documents



ID: 546571.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2010-arch
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project
Authors:Gerstein, Mark; Lu, Zhi John; Van Nostrand, Eric L.; Cheng, Chao; Arshinoff, Bradley I.; Liu, Tao; Yip, Kevin Y.; Robilotto, Rebecca; Rechtsteiner, Andreas; Ikegami, Kohta; Alves, Pedro; Chateigner, Aurelien; Perry, Marc; Morris, Mitzi; Auerbach, Raymond; Feng, Xin; Leng, Jing; Vielle, Anne; Niu, Wei; Rhrissorrakrai, Kahn; Agarwal, Ashish; Alexander, Roger P.; Barber, Galt; Brdlik, Cathleen M; Brennan, Jennifer; Brouillet, Jeremy Jean; Carr, Adrian; Cheung, Ming-Sin; Clawson, Hiram; Contrino, Sergio; Dannenberg, Luke O.; Dernburg, Abby F.; Desai, Arshad; Dick, Lindsay; Dosé, Andréa; Du, Jiang; Egelhofer, Thea; Ercan, Sevinc; Euskirchen, Ghia; Ewing, Brent; Feingold, Elise A.; Gassmann, Reto; Good, Peter J.; Green, Phil; Gullier, Francois; Gutwein, Michelle; Guyer, Mark S.; Habegger, Lukas; Han, Ting; Henikoff, Jorja G.; Henz, Stefan R.; Hinrichs, Angie; Holster, Heather; Hyman, Anthony A.; Iniguez, A. Leo; Janette, Judith; Jensen, Morten; Kato, Masaomi; Kent, W. James; Kephart, Ellen; Khivansara, Vishal; Khurana, Ekta; Kim, John K.; Kolasinska-Zwierz, Paulina; Lai, Eric C; Latorre, Isabel; Leahey, Amber; Lewis, Suzanna E; Lloyd, Paul; Lochovsky, Lucas; Lowdon, Rebecca F.; Lubling, Yaniv; Lyne, Rachel; MacCoss, Michael; Mackowiak, Sebastian D.; Mangone, Marco; McKay, Sheldon; Mecenas, Desirea; Merrihew, Gennifer; Miller, David M.; Muroyama, Andrew; Murray, John I.; Ooi, Siew-Loon; Pham, Hoang; Phippen, Taryn; Preston, Elicia A.; Rajewski, Nikolaus; Rätsch, Gunnar; Rosenbaum, Heidi; Rozowksy, Joel; Rutherford, Kim; Ruzanov, Peter; Sarov, Mihail; Sasidharan, Rajkumar; Sboner, Andrea; Scheid, Paul; Segal, Eran; Shin, Hyunjin; Shou, Chong; Slack, Frank J.; Slightham, Cindie; Smith, Richard; Spencer, William C.; Stinson, E. O.; Taing, Scott; Takasaki, Teruaki; Vafeados, Dionne; Voronina, Ksenia; Wang, Guilin; Washington, Nicole L.; Whittle, Christina M.; Wu, Beijing; Yang, Koon-Kiu; Zeller, Georg; Zha, Zheng; Zhong, Mei; Zhou, Xingliang; Ahringer, Julie; Strome, Susan; Gunsalus, Kristin C.; Micklem, Gos; Liu, X. Shirley; Reinke, Valerie; Kim, Stuart K; Hillier, LaDeana W; Henikoff, Steven; Piano, Fabio; Snyder, Michael; Stein, Lincoln; Lieb, Jason D.; Waterston, Robert H
Date of Publication (YYYY-MM-DD):2010
Title of Journal:Science (New York, N.Y.)
Volume:330
Issue / Number:6012
Start Page:1775
End Page:1787
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:We systematically generated large-scale data sets to improve genome annotation for the nematode Caenorhabditis elegans, a key model organism. These data sets include transcriptome profiling across a developmental time course, genome-wide identification of transcription factor–binding sites, and maps of chromatin organization. From this, we created more complete and accurate gene models, including alternative splice forms and candidate noncoding RNAs. We constructed hierarchical networks of transcription factor–binding and microRNA interactions and discovered chromosomal locations bound by an unusually large number of transcription factors. Different patterns of chromatin composition and histone modification were revealed between chromosome arms and centers, with similarly prominent differences between autosomes and the X chromosome. Integrating data types, we built statistical models relating chromatin, transcription factor binding, and gene expression. Overall, our analyses ascribed putative functions to most of the conserved genome.
External Publication Status:published
Document Type:Article
Communicated by:nn
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:4414
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.