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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2010-arch     Display Documents



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ID: 546603.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2010-arch
Wnt5a/Ror2-induced upregulation of xPAPC requires xShcA.
Authors:Feike, Ann Caroline; Rachor, Klara; Gentzel, Marc; Schambony, Alexandra
Date of Publication (YYYY-MM-DD):2010
Title of Journal:Biochemical and Biophysical Research Communications
Volume:400
Issue / Number:4
Start Page:500
End Page:506
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Ror receptor-tyrosine kinases act as Wnt-5a receptors in beta-catenin independent Wnt-signaling pathways. In Xenopus, expression of xPAPC is regulated by a Wnt-5a/Ror2 pathway, which resembles typical signaling cascades downstream of receptor-tyrosine kinases. Here, we have identified the phospho-tyrosine binding protein ShcA as an intracellular binding partner of Ror2. ShcA binds to a conserved motif in Ror2 via its SH2-domain. Wnt-5a induces clustering of Ror2 in the cell membrane and recruitment of ShcA to the Ror2 receptor complex. We further show that ShcA is co-expressed with Ror2 in developing Xenopus embryos and ShcA is required for Wnt-5a/Ror2 mediated upregulation of xPAPC, demonstrating the functional relevance of this interaction.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:nn
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:4448
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