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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2010-arch     Display Documents



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ID: 546690.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2010-arch
Evidence that the tumor-suppressor protein BRCA2 does not regulate cytokinesis in human cells.
Authors:Lekomtsev, Sergey; Guizetti, Julien; Pozniakovsky, Andrei I.; Gerlich, Daniel W; Petronczki, Mark
Date of Publication (YYYY-MM-DD):2010
Title of Journal:Journal of Cell Science
Volume:123
Issue / Number:Pt 9
Start Page:1395
End Page:1400
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Germline mutations in the tumor-suppressor gene BRCA2 predispose to breast and ovarian cancer. BRCA2 plays a well-established role in maintaining genome stability by regulating homologous recombination. BRCA2 has more recently been implicated in cytokinesis, the final step of cell division, but the molecular basis for this remains unknown. We have used time-lapse microscopy, recently developed cytokinesis assays and BAC recombineering (bacterial artificial chromosome recombinogenic engineering) to investigate the function and localization of BRCA2 during cell division. Our analysis suggests that BRCA2 does not regulate cytokinesis in human cells. Thus, cytokinesis defects are unlikely to contribute to chromosomal instability and tumorigenesis in BRCA2-related cancers.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:nn
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:4403
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