Please note that eDoc will be permanently shut down in the first quarter of 2021!      Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ
Home Search Quick Search Advanced Fulltext Browse Collections Persons My eDoc Session History Login Name: Password: Documentation Help Support Wiki Direct access to document ID:	Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2010-arch     Display Documents ID: 546695.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2010-arch Microtubules and motor proteins: Mechanically regulated self-organization in vivo Authors: Vogel, Sven; Pavin, Nenad; Maghelli, Nicola; Jülicher, Frank; Tolic-Norrelykke, Iva M. Date of Publication (YYYY-MM-DD): 2010 Title of Journal: European Physical Journal Special Topics Volume: 178 Issue / Number: 1 Start Page: 57 End Page: 69 Copyright: not available Audience: Experts Only Intended Educational Use: No Abstract / Description: A key aspect of life is sexual reproduction, which requires concerted movement. For successful mixing of the genetic material, molecular motors move the nucleus back and forth inside the cell. How motors work together to produce these large-scale movements, however, remains a mystery. To answer this question, we studied nuclear movement in fission yeast, which is driven by motor proteins pulling on microtubules. We show that motor proteins dynamically redistribute from one part of the cell to the other, generating asymmetric patterns of motors and, consequently, of forces that generate movement. By combining quantitative live cell imaging and laser ablation with a theoretical model, we find that this dynamic motor redistribution occurs purely as a result of changes in the mechan- ical strain sensed by the motor proteins. Our work therefore demonstrates that spatio-temporal pattern formation within a cell can occur as a result of mechani- cal cues (Vogel et al., 2009), which differs from conventional molecular signaling, as well as from self-organization based on a combination of biochemical reactions and diffusion. External Publication Status: published Document Type: Article Communicated by: nn Affiliations: MPI für molekulare Zellbiologie und Genetik Identifiers: LOCALID:4103 The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.