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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2010-arch     Display Documents



ID: 546721.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2010-arch
Axon extension occurs independently of centrosomal microtubule nucleation.
Authors:Stiess, Michael; Maghelli, Nicola; Kapitein, Lukas C; Gomis-Rüth, Susana; Wilsch-Bräuninger, Michaela; Hoogenraad, Casper C; Tolic-Norrelykke, Iva M.; Bradke, Frank
Date of Publication (YYYY-MM-DD):2010
Title of Journal:Science (New York, N.Y.)
Volume:327
Issue / Number:5966
Start Page:704
End Page:707
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Microtubules are polymeric protein structures and components of the cytoskeleton. Their dynamic polymerization is important for diverse cellular functions. The centrosome is the classical site of microtubule nucleation and is thought to be essential for axon growth and neuronal differentiation--processes that require microtubule assembly. We found that the centrosome loses its function as a microtubule organizing center during development of rodent hippocampal neurons. Axons still extended and regenerated through acentrosomal microtubule nucleation, and axons continued to grow after laser ablation of the centrosome in early neuronal development. Thus, decentralized microtubule assembly enables axon extension and regeneration, and, after axon initiation, acentrosomal microtubule nucleation arranges the cytoskeleton, which is the source of the sophisticated morphology of neurons.
External Publication Status:published
Document Type:Article
Communicated by:nn
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:4101
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