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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents



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ID: 547488.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
Minimum information about a protein affinity reagent (MIAPAR)
Authors:Bourbeillon, Julie; Orchard, Sandra; Benhar, Itai; Borrebaeck, Carl; de Daruvar, Antoine; Dubel, Stefan; Frank, Ronald; Gibson, Frank; Gloriam, David; Haslam, Niall; Hiltker, Tara; Humphrey-Smith, Ian; Hust, Michael; Juncker, David; Koegl, Manfred; Konthur, Zoltàn; Korn, Bernhard; Krobitsch, Sylvia; Muyldermans, Serge; Nygren, Per-Åke; Palcy, Sandrine; Polic, Bojan; Rodriguez, Henry; Sawyer, Allan; Schlapshy, Martin; Snyder, Michael; Stoevesandt, Oda; Taussig, Michael J.; Templin, Markus; Uhlen, Matthias; van der Maarel, Silvere; Wingren, Christer; Hermjakob, Henning; Sherman, David
Language:English
Date of Publication (YYYY-MM-DD):2010-07
Title of Journal:Nature biotechnology
Journal Abbrev.:Nat Biotechnol
Volume:28
Issue / Number:7
Start Page:650
End Page:653
Copyright:© 2010 Nature Publishing Group
Review Status:not specified
Audience:Experts Only
Abstract / Description:We wish to alert your readers to MIAPAR, the minimum information about a protein affinity reagent. This is a proposal developed within the community as an important first step in formalizing standards in reporting the production and properties of protein binding reagents, such as antibodies, developed and sold for the identification and detection of specific proteins present in biological samples. It defines a checklist of required information, intended for use by producers of affinity reagents, quality-control laboratories, users and databases (Supplementary Table 1). We envision that both commercial and freely available affinity reagents, as well as published studies using these reagents, could include a MIAPAR-compliant document describing the product's properties with every available binding partner. This would enable the user or reader to make a fully informed evaluation of the validity of conclusions drawn using this reagent (Fig. 1).
Free Keywords:Affinity Labels; Indicators and Reagents/chemistry; Proteins/chemistry
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:INRIA Bordeaux–Sud-Ouest, MAGNOME project team, Talence, France
European Molecular Biology Laboratory–European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
Department of Molecular Microbiology and Biotechnology, Tel-Aviv University, Ramat Aviv, Israel
Department of Immunotechnology, Lund University, Lund, Sweden
Université de Bordeaux, Centre de Bioinformatique de Bordeaux, Bordeaux, France
Technische Universität Braunschweig, Institute of Biochemistry and Biotechnology, D-38106 Braunschweig, Germany
Helmholtz Center for Infection Research, Braunschweig, Germany
AbCam, Cambridge, UK
Medicinal Chemistry, Pharmaceutical Faculty, Copenhagen University, Copenhagen, Denmark
Complex and Adaptive Systems Laboratory, University College, Dublin, Ireland
Clinical Proteomic Technologies for Cancer, National Cancer Institute, Bethesda, Maryland, USA
Deomed Limited, Newcastle-upon-Tyne, UK
Biomedical Engineering Department, McGill University and Genome Quebec Innovation Centre, McGill University, Montreal, Canada
German Cancer Research Center, Heidelberg, Germany
Department of Molecular and Cellular Interactions, Vrije Univeristeit Brussel, Brussels, Belgium
Royal Institute of Technology, AlbaNova University Center, Stockholm, Sweden
Medical Faculty University of Rijeka, Rijeka, Croatia
European Molecular Biology Laboratory Monoclonal Core Facility, Monterotondo-Scalo, Italy
Technische Universität München, Munich, Germany
Stanford University School of Medicine, Department of Genetics, Stanford, California, USA.
Babraham Bioscience Technologies, Babraham, Cambridge, UK.
Natural and Medical Science Institute, University of Tübingen, Tübingen, Germany
Royal Institute of Technology, AlbaNova University Center, Stockholm, Sweden
Universiteit Leiden, Leiden, The Netherlands.
Identifiers:ISSN:1546-1696 (Electronic) [ID No:1]
DOI:10.1038/nbt0710-650 [ID No:2]
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