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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents

ID: 547656.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
The genome of a songbird.
Authors:Warren, W. C.; Clayton, D. F.; Ellegren, H.; Arnold, A. P.; Hillier, L. W.; Kunstner, A.; Searle, S.; White, S.; Vilella, A. J.; Fairley, S.; Heger, A.; Kong, L.; Ponting, C. P.; Jarvis, E. D.; Mello, C. V.; Minx, P.; Lovell, P.; Velho, T. A.; Ferris, M.; Balakrishnan, C. N.; Sinha, S.; Blatti, C.; London, S. E.; Li, Y.; Lin, Y. C.; George, J.; Sweedler, J.; Southey, B.; Gunaratne, P.; Watson, M.; Nam, K.; Backstrom, N.; Smeds, L.; Nabholz, B.; Itoh, Y.; Whitney, O.; Pfenning, A. R.; Howard, J.; Volker, M.; Skinner, B. M.; Griffin, D. K.; Ye, L.; McLaren, W. M.; Flicek, P.; Quesada, V.; Velasco, G.; Lopez-Otin, C.; Puente, X. S.; Olender, T.; Lancet, D.; Smit, A. F.; Hubley, R.; Konkel, M. K.; Walker, J. A.; Batzer, M. A.; Gu, W.; Pollock, D. D.; Chen, L.; Cheng, Z.; Eichler, E. E.; Stapley, J.; Slate, J.; Ekblom, R.; Birkhead, T.; Burke, T.; Burt, D.; Scharff, C.; Adam, I.; Richard, H.; Sultan, M.; Soldatov, A.; Lehrach, H.; Edwards, S. V.; Yang, S. P.; Li, X.; Graves, T.; Fulton, L.; Nelson, J.; Chinwalla, A.; Hou, S.; Mardis, E. R.; Wilson, R. K.
Date of Publication (YYYY-MM-DD):2010-04-01
Title of Journal:Nature
Journal Abbrev.:Nat
Issue / Number:7289
Start Page:757
End Page:762
Copyright:© 2011 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Review Status:not specified
Audience:Experts Only
Abstract / Description:The zebra finch is an important model organism in several fields with unique relevance to human neuroscience. Like other songbirds, the zebra finch communicates through learned vocalizations, an ability otherwise documented only in humans and a few other animals and lacking in the chicken-the only bird with a sequenced genome until now. Here we present a structural, functional and comparative analysis of the genome sequence of the zebra finch (Taeniopygia guttata), which is a songbird belonging to the large avian order Passeriformes. We find that the overall structures of the genomes are similar in zebra finch and chicken, but they differ in many intrachromosomal rearrangements, lineage-specific gene family expansions, the number of long-terminal-repeat-based retrotransposons, and mechanisms of sex chromosome dosage compensation. We show that song behaviour engages gene regulatory networks in the zebra finch brain, altering the expression of long non-coding RNAs, microRNAs, transcription factors and their targets. We also show evidence for rapid molecular evolution in the songbird lineage of genes that are regulated during song experience. These results indicate an active involvement of the genome in neural processes underlying vocal communication and identify potential genetic substrates for the evolution and regulation of this behaviour.
Comment of the Author/Creator:Correspondence to: Wesley C. Warren1David F. Clayton2Hans Ellegren3Arthur P. Arnold4 Correspondence and requests for materials should be addressed to W.C.W.
(Email:, D.F.C
(Email:, H.E.
(Email: or A.P.A.
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:1.The Genome Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA;
2.University of Illinois, Urbana-Champaign, Illinois 61801 USA;
3.Uppsala University, Institute for Evolution and Genetics Systems, Norbyvägen 18D 752 36 Uppsala, Sweden;
4.University of California- Los Angeles, Los Angeles, California 90056, USA;
5.Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK;
6.EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK;
7.MRC Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK;
8.Howard Hughes Medical Institute, Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, North Carolina 27710, USA;
9.Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon 97239, USA;
10.Department of Biology & Biochemistry, University of Houston, Houston, Texas 77204, USA;
11.Department of Bioinformatics, Institute for Animal Health, Compton Berks RG20 7NN, UK;
12.Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK;
13.Instituto Universitario de Oncologia, Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, 33006-Oviedo, Spain;
14.Crown Human Genome Center, Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel;
15.Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103-8904, USA;
16.Department of Biological Sciences, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA;
17.Department of Biochemistry & Molecular Genetics, University of Colorado Health Sciences Center, Mail Stop 8101, Aurora, Colorado 80045, USA;
18. University of Washington, Genome Sciences, Seattle, Washington 98195, USA;
19.Department of Animal & Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK;
20.The Roslin Institute and Royal (Dick) School of of Veterinary Studies, Edinburgh University, EH25 9OS, UK;
21.Freie Universitaet Berlin, Institut Biology, Takustr.6, 14195 Berlin, Germany;
22.Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA;
23.Monsanto Company, 800 North Lindbergh Boulevard, St Louis, Missouri 63167, USA.
24.Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
Identifiers:ISSN:0028-0836 [ID No:1]
URL: [ID No:2]
DOI:10.1038/nature08819 [ID No:3]
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