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          Institute: MPI für biologische Kybernetik     Collection: Biologische Kybernetik     Display Documents



ID: 548409.0, MPI für biologische Kybernetik / Biologische Kybernetik
Synthesis and characterization of dinuclear heterometallic lanthanide complexes exhibiting MRI and luminescence response
Authors:Mamedov, I.; Parac-Vogt, T.N.; Logothetis, N.K.; Angelovski, G.
Date of Publication (YYYY-MM-DD):2010-05
Title of Journal:Dalton Transactions
Volume:39
Issue / Number:24
Start Page:5721
End Page:5727
Audience:Not Specified
Intended Educational Use:No
Abstract / Description:A molecule bearing a macrocyclic DOTA-type chelator and an acyclic chelator based on the 5-aminoisophthalamide diethylenediaminetetraacid (5A-PADDTA) was synthesized by linking these two moieties via an
amide bond. The ligand has the possibility to complex two identical or different lanthanide ions, depending on the desire for its potential application. Luminescence studies involving titrations of the
Eu3+ or Gd3+ complex with Tb3+ confirm the formation of heterometallic complexes, as well as the presence of different species in the solution. Comparative 1H NMR spectra of the ligand, its Eu3+ complex, and that
containing both Eu3+ and Tb3+ proves the existence of respective monometallic or bimetallic species. NMR diffusion measurements on 5A-PADDTA as a model compound indicate the formation of aggregates upon the
addition of Y3+ (chosen as a diamagnetic analogue of lanthanide ions). Hydration values were calculated from the respective luminescence lifetime values. They show the dominance of a q = 1 species for both ions in
monometallic complexes, or q = 1 and q = 2 species of ions in aggregated complexes, for DOTA and 5A-PADDTA chelators, respectively.
External Publication Status:published
Document Type:Article
Communicated by:Holger Fischer
Affiliations:MPI für biologische Kybernetik/Neurophysiology (Dept. Logothetis)
Identifiers:LOCALID:6594
URL:http://www.rsc.org/ej/DT/2010/b925556g.pdf
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