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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents



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ID: 548927.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
The caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling.
Authors:von Kampen, O.; Lipinski, S.; Till, A.; Martin, S. J.; Nietfeld, W.; Lehrach, H.; Schreiber, S.; Rosenstiel, P.
Language:English
Date of Publication (YYYY-MM-DD):2010-04-12
Title of Journal:He Journal of Biological Chemistry
Journal Abbrev.:J Biol Chem
Volume:285
Issue / Number:26
Start Page:19921
End Page:19926
Copyright:© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.
Review Status:not specified
Audience:Experts Only
Abstract / Description:Caspase activating and recruitment domain 8 (CARD8) has been implicated as a co-regulator of several pro-inflammatory and apoptotic signaling pathways. In the present study, we demonstrate a specific modulation of NOD2-induced signaling by CARD8 in intestinal epithelial cells. We show that CARD8 physically interacts with NOD2 and inhibits nodosome assembly and subsequent signaling upon muramyl-dipeptide stimulation. Furthermore, CARD8 inhibits the direct bactericidal effect of NOD2 against intracellular infection by Listeria monocytogenes. Thus, CARD8 represents a novel molecular switch involved in the endogenous regulation of NOD2-dependent inflammatory processes in epithelial cells.
Free Keywords:Immunology
Inflammation
NF-κB
Protein-Protein Interactions
Signal Transduction
CARD8
Caspase Recruitment Domain
Crohn Disease
NOD2
Comment of the Author/Creator:Institute of Clinical Molecular Biology, Christian-Albrechts-University, Schittenhelmstr. 12, D-24105 Kiel, Germany. Tel.: 49-431-597-2350; Fax: 49-431-597-4264; E-mail: p.rosenstiel@mucosa.de.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:1.Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel D-24105, Germany;
2.Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland.
Identifiers:ISSN:0021-9258 [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=... [ID No:2]
DOI:10.1074/jbc.M110.127480 [ID No:3]
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