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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents



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ID: 552742.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects.
Authors:Sleegers, K.; Lambert, J. C.; Bertram, L.; Cruts, M.; Amouyel, P.; Van Broeckhoven, C.
Language:English
Date of Publication (YYYY-MM-DD):2010-01-18
Title of Journal:Trends in Genetics
Journal Abbrev.:Trends Genet
Volume:26
Issue / Number:2
Start Page:84
End Page:93
Copyright:© 2010 Elsevier Ltd All rights reserved.
Review Status:not specified
Audience:Experts Only
Abstract / Description:The recent discoveries in genome-wide association studies (GWAS) of novel susceptibility loci (CLU, CR1 and PICALM) for Alzheimer's disease (AD) have elicited considerable interest in the AD community. But what are the implications of these purely epidemiological findings for our understanding of disease etiology and patient care? In this review, we attempt to place these findings in the context of current and future AD genetics research. CLU, CR1 and PICALM support existing hypotheses about the amyloid, lipid, chaperone and chronic inflammatory pathways in AD pathogenesis. We discuss how these and future findings can be translated into efforts to ameliorate patient care by genetic profiling for risk prediction and pharmacogenetics and by guiding drug development.
Free Keywords:Alzheimer Disease;
drug therapy/genetics/metabolism/pathology;
Animals;
Disease Progression;
Drug Design;
Gene Expression Profiling;
Genetic Predisposition to Disease;
Humans;
Risk Factors
Comment of the Author/Creator:Email:christine.vanbroeckhoven@molgen.vib-ua.be
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:1.Neurodegenerative Brain Diseases Group, VIB-Department of Molecular Genetics; Universiteitsplein 1, B-2610 Antwerp, Belgium;
2.Laboratory of Neurogenetics, Institute Born-Bunge and University of Antwerp; Universiteitsplein 1, B-2610 Antwerp, Belgium;
3.Inserm U744; Institut Pasteur de Lille; Université de Lille Nord de France; Rue Calmette 1, 59019 Lille cedex, France.
Identifiers:ISSN:0168-9525 [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=... [ID No:2]
DOI:10.1016/j.tig.2009.12.004 [ID No:3]
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