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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents



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ID: 552745.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
Automation in the high-throughput selection of random combinatorial libraries-different approaches for select applications
Authors:Glökler, J.; Schütze, T.; Konthur, Z.
Language:English
Date of Publication (YYYY-MM-DD):2010-04
Title of Journal:Molecules
Volume:15
Issue / Number:4
Start Page:2478
End Page:2490
Copyright:© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland
Review Status:not specified
Audience:Experts Only
Abstract / Description:Automation in combination with high throughput screening methods has revolutionised molecular biology in the last two decades. Today, many combinatorial libraries as well as several systems for automation are available. Depending on scope, budget and time, a different combination of library and experimental handling might be most effective. In this review we will discuss several concepts of combinatorial libraries and provide information as what to expect from these depending on the given context.
Free Keywords:Automation, Laboratory; Combinatorial Chemistry Techniques; High-Throughput Screening Assays; Peptide Library; Robotics; SELEX Aptamer Technique; Small Molecule Libraries/chemistry
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:Institute for Chemistry/ Biochemistry, Free University Berlin, Thielallee 63, 14195 Berlin, Germany
Identifiers:ISSN:1420-3049 (Electronic) [ID No:1]
DOI:10.3390/molecules15042478 [ID No:2]
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