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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents



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ID: 554590.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation
Authors:Haapasalo, A.; Viswanathan, J.; Bertram, L.; Soininen, H.; Tanzi, R. E.; Hiltunen, M.
Language:English
Date of Publication (YYYY-MM-DD):2010-02
Title of Journal:Biochemical Society Transactions
Journal Abbrev.:Biochem Soc Trans
Volume:38
Start Page:150
End Page:155
Copyright:© The Authors Journal compilation © 2010 Biochemical Society
Review Status:not specified
Audience:Experts Only
Abstract / Description:Abnormal protein aggregation and intracellular or extracellular accumulation of misfolded and aggregated proteins are key events in the pathogenesis of different neurodegenerative diseases. Furthermore, endoplasmic reticulum stress and impairment of the ubiquitin-proteasome system probably contribute to neurodegeneration in these diseases. A characteristic feature of AD (Alzheimer's disease) is the abnormal accumulation of Abeta (amyloid beta-peptide) in the brain. Evidence shows that the AD-associated PS (presenilin) also forms aggregates under certain conditions and that another AD-associated protein, ubiquilin-1, controls protein aggregation and deposition of aggregated proteins. Here, we review the current knowledge of ubiquilin-1 and PS in protein aggregation and related events that potentially influence neurodegeneration.
Free Keywords:Alzheimer Disease/metabolism/pathology; Amyloid beta-Peptides/metabolism; Carrier Proteins/chemistry/genetics/metabolism; Cell Cycle Proteins/chemistry/genetics/metabolism; Endoplasmic Reticulum/metabolism; Humans; Inclusion Bodies/metabolism; Oxidative Stress; Presenilins/metabolism; Proteasome Endopeptidase Complex/metabolism; Protein Conformation; Protein Folding
Comment of the Author/Creator:E-mail mikko.hiltunen@uku.fi
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:Department of Neurology, University of Kuopio, and Kuopio University Hospital, Kuopio, Finland
Genetics and Aging Research Unit, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129, U.S.A.
Identifiers:ISSN:1470-8752 (Electronic) [ID No:1]
DOI:10.1042/BST0380150 [ID No:2]
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