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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents



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ID: 556524.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.
Authors:Laumet, G.; Chouraki, V.; Grenier-Boley, B.; Legry, V.; Heath, S.; Zelenika, D.; Fievet, N.; Hannequin, D.; Delepine, M.; Pasquier, F.; Hanon, O.; Brice, A.; Epelbaum, J.; Berr, C.; Dartigues, J. F.; Tzourio, C.; Campion, D.; Lathrop, M.; Bertram, L.; Amouyel, P.; Lambert, J. C.
Language:English
Date of Publication (YYYY-MM-DD):2010
Title of Journal:Journal of Alzheimer's Disease
Journal Abbrev.:J Alzheimers Dis
Volume:20
Issue / Number:4
Start Page:1181
End Page:1188
Copyright:2010 – IOS Press and the authors. All rights reserved
Review Status:not specified
Audience:Experts Only
Abstract / Description:We selected twenty genes from the "Top Results" list on the AlzGene database website and assessed their association with risk of developing Alzheimer's disease (AD) in a large, genome-wide association study (using 526 SNPs from 2,032 AD cases and 5,328 controls) performed in France. The APOE, CLU, PICALM, and CR1 loci were excluded, since they had already been extensively analyzed. Ten genes/loci (TFAM, SORL1, CHRNB2, SORCS1, DAPK1, MTHFR, GWA 14q32.13, BDNF, NEDD9, and CH25H) showed weak nominal association with AD risk, in line with previous studies. In the remaining ten genes/loci (TNK1, ACE, CST3, IL1B, hCG2039140, PRNP, GAB2, LOC651924, IL1A, and TF), no single nucleotide polymorphisms were associated in our dataset. Of the genes showing nominal association in our cohorts, TFAM and CHRNB2 appear particularly interesting and warrant further genetic and functional follow-up analyses.
Free Keywords:AlzGene database;
Alzheimer's disease;
association;
GWAS;
replication;
risk factor;
SNPs
Comment of the Author/Creator:Correspondence to: Jean-Charles Lambert, Unit´e INSERM744,
Institut Pasteur de Lille, BP 245,1, rue du professeur Calmette, F-59019 Lille cedex, France.
Tel.: +33 (0)3 20 87 73 91; Fax: +33
(0)3 20 87 78 94; E-mail: jean-charles.lambert@pasteur-lille.fr.
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:1.INSERM U744, Lille, France;
2.Institut Pasteur de Lille, Lille, France;
3.Université de Lille Nord de France, Lille, France;
4.Centre National de Génotypage, Institut Génomique, Commissariat à l'Energie Atomique, Evry, France;
5.INSERM U614, Faculté de Médecine-Pharmacie de Rouen, Rouen, France;
6.CHRU de Lille, Lille, France;
7.UMR 894, Inserm Faculté de Médecine, Université Paris Descartes, Paris, France;
8.Inserm, UMR_S679, Hôpital de la Salpêtrière, Paris, France;
9.INSERM U888, Hôpital La Colombière, Montpellier, France;
10.INSERM U897, Victor Segalen University, Bordeaux, France;
11.INSERM U708, Paris, France;
12.UPMC Univ Paris 06, Paris, France;
13.Fondation Jean Dausset- CEPH, Paris, France.
Identifiers:ISSN:1387-2877 [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=... [ID No:2]
DOI:10.3233/JAD-2010-100126 [ID No:3]
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