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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents



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ID: 556531.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study
Authors:Lambert, J. C.; Sleegers, K.; Gonzalez-Perez, A.; Ingelsson, M.; Beecham, G. W.; Hiltunen, M.; Combarros, O.; Bullido, M. J.; Brouwers, N.; Bettens, K.; Berr, C.; Pasquier, F.; Richard, F.; Dekosky, S. T.; Hannequin, D.; Haines, J. L.; Tognoni, G.; Fievet, N.; Dartigues, J. F.; Tzourio, C.; Engelborghs, S.; Arosio, B.; Coto, E.; De Deyn, P.; Del Zompo, M.; Mateo, I.; Boada, M.; Antunez, C.; Lopez-Arrieta, J.; Epelbaum, J.; Schjeide, B. M.; Frank-Garcia, A.; Giedraitis, V.; Helisalmi, S.; Porcellini, E.; Pilotto, A.; Forti, P.; Ferri, R.; Delepine, M.; Zelenika, D.; Lathrop, M.; Scarpini, E.; Siciliano, G.; Solfrizzi, V.; Sorbi, S.; Spalletta, G.; Ravaglia, G.; Valdivieso, F.; Vepsalainen, S.; Alvarez, V.; Bosco, P.; Mancuso, M.; Panza, F.; Nacmias, B.; Bossu, P.; Hanon, O.; Piccardi, P.; Annoni, G.; Mann, D.; Marambaud, P.; Seripa, D.; Galimberti, D.; Tanzi, R. E.; Bertram, L.; Lendon, C.; Lannfelt, L.; Licastro, F.; Campion, D.; Pericak-Vance, M. A.; Soininen, H.; Van Broeckhoven, C.; Alperovitch, A.; Ruiz, A.; Kamboh, M. I.; Amouyel, P.
Language:English
Date of Publication (YYYY-MM-DD):2010
Title of Journal:J Alzheimers Dis
Journal Abbrev.:Journal of Alzheimers Disease
Volume:22
Issue / Number:1
Start Page:247
End Page:255
Copyright:© 2010 IOS Press
Review Status:not specified
Audience:Experts Only
Abstract / Description:The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the epsilon4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the epsilon4 allele of the APOE gene.
Free Keywords:Age at onset; Alzheimer's disease; apolipoprotein E; CALHM1; polymorphism
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:1INSERM U744, Lille, France
2Institut Pasteur de Lille, Lille, France
3Université de Lille Nord de France, Lille, France
4Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium
5Institute Born-Bunge and University of Antwerp, Antwerp, Belgium
6Department of Structural Genomics. Neocodex, Sevilla, Spain
7Uppsala University, Stockholm, Sweden
8John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL, USA
9Department of Neurology, Kuopio University and University Hospital, Kuopio, Finland
10Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria), Santander, Spain
11Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, Madrid, Spain
12INSERM U888, Hôpital La Colombière, Montpellier, France
13CHRU de Lille, Lille, France
14University of Virginia School of medicine, Charlottesville, VA, USA
15INSERM U614, Faculté de Médecine-Pharmacie de Rouen, Rouen, France
16Vanderbilt Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA
17Department of Neuroscience, Neurological Clinic, University of Pisa, Pisa, Italy
18INSERM U897, Victor Segalen University, Bordeaux, France
19INSERM U708, Paris, France
20UPMC Univ. Paris 06, Paris, France
21Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium
22Department of Internal Medicine, Fondazione Policlinico IRCCS, Milan, Italy
23Genetic Molecular Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
24Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari, Cagliari, Italy
25Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain
26Neurology Department, Hospital G. Universitari Vall d'Hebron, Barcelona, Spain
27Alzheimur Foundation, Murcia, Spain
28Dementia Unit. University Hospital Virgen de la Arrixaca, Murcia, Spain
29Memory Unit. University Hospital La Paz- Cantoblanco, Madrid, Spain
30UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, Paris, France
31Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin, Germany
32Servicio de Neurologia, Hospital Universitario La Paz (UAM) and CIBERNED, Madrid, Spain
33Department of Experimental Pathology, School of Medicine, University of Bologna, Bologna, Italy
34Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
35Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna, Italy
36IRCCS Oasi Maria SS, Troina, Italy
37Centre National de Genotypage, Institut Genomique, Commissariat à l'Énergie Atomique, Evry, France
38Fondation Jean Dausset-CEPH, Paris, France
39Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
40Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, Bari, Italy
41Department of Neurological and Psychiatric Sciences, Florence, Italy
42Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Roma, Italy
43Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza, Italy
44Greater Manchester Neuroscience Centre, University of Manchester, Manchester, UK
45Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institute for Medical Research, North Shore-LIJ, Manhasset, NY, USA
46Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
47Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA, USA
48Molecular Psychiatry Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland, Australia
49Department of Human Genetics and Alzheimer's Disease Research Centre, University of Pittsburgh, Pittsburgh, PA, USA
Identifiers:ISSN:1875-8908 (Electronic) [ID No:1]
DOI:10.3233/JAD-2010-100933 [ID No:2]
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