MPI für Evolutionsbiologie / Evolutionary genetics |
|Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1A is associated with BMI in Tongans|
|Authors:||Myles, Sean; Lea, Rod A.; Ohashi, Jun; Chambers, Geoff K.; Weiss, Joerg G.; Hardouin, Emilie; Engelken, Johannes; Macartney-Coxson, Donia P.; Eccles, David A.; Naka, Izumi; Kimura, Ryosuke; Inaoka, Tsukasa; Matsumura, Yasuhiro; Stoneking, Mark|
|Date of Publication (YYYY-MM-DD):||2011-01-18|
|Title of Journal:||Biomedcentral Medical Genetics|
|Journal Abbrev.:||BMC Medical Genetics|
|Sequence Number of Article:||10|
|Review Status:||not specified|
|Abstract / Description:||Background: The thrifty gene hypothesis posits that, in populations that experienced periods of feast and famine, natural selection favoured individuals carrying thrifty alleles that promote the storage of fat and energy. Polynesians likely experienced long periods of cold stress and starvation during their settlement of the Pacific and today have high rates of obesity and type 2 diabetes (T2DM), possibly due to past positive selection for thrifty alleles. Alternatively, T2DM risk alleles may simply have drifted to high frequency in Polynesians. To identify thrifty alleles in Polynesians, we previously examined evidence of positive selection on T2DM-associated SNPs and identified a T2DM risk allele at unusually high frequency in Polynesians. We suggested that the risk allele of the Gly482Ser variant in the PPARGC1A gene was driven to high frequency in Polynesians by positive selection and therefore possibly represented a thrifty allele in the Pacific.
Methods: Here we examine whether PPARGC1A is a thrifty gene in Pacific populations by testing for an association between Gly482Ser genotypes and BMI in two Pacific populations (Maori and Tongans) and by evaluating the frequency of the risk allele of the Gly482Ser variant in a sample of worldwide populations.
Results: We find that the Gly482Ser variant is associated with BMI in Tongans but not in Maori. In a sample of 58 populations worldwide, we also show that the 482Ser risk allele reaches its highest frequency in the Pacific.
Conclusion: The association between Gly482Ser genotypes and BMI in Tongans together with the worldwide frequency distribution of the Gly482Ser risk allele suggests that PPARGC1A remains a candidate thrifty gene in Pacific populations.
|External Publication Status:||published|
|Version Comment:||Automatic journal name synchronization|
|Communicated by:||Brigitte Lechner|
|Affiliations:||MPI für Evolutionsbiologie/Abt. Evolutionsgenetik|
|External Affiliations:||Cornell Univ, Inst Genom Divers, Ithaca, NY 14853 USA; Cornell Univ, Dept Biol Stat & Computat Biol, Ithaca, NY USA; Acadia Univ, Dept Biol, Wolfville, NS B0P 1X0 Canada; Inst Environm Sci & Res Ltd, Porirua, New Zealand; Univ Tsukuba, Grad Sch Comprehens Human Sci, Doctoral Program Life Syst Med Sci, Ibaraki, Japan; Victoria Univ Wellington, Sch Biol Sci, Wellington, New Zealand; Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, Leipzig, Germany; Univ Ryukyus, TRO SIS, Okinawa, Japan; Saga Univ, Fac Agr, Dept Human Ecol, Saga 840, Japan; Kiryu Univ, Fac Hlth Care, Gunma, Japan; Pompeu Fabra Univ, Inst Evolutionary Biol, Barcelona, Spain|
|Identifiers:||ISSN:1471-2350 [ID-No:1] |
LOCALID:2829/S 39172 [Listen-Nummer/S-Nummer]
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|Myles_2011.pdf [396,00 Kb] |
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