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          Institute: MPI für Neurobiologie     Collection: Axonal Growth and Regeneration     Display Documents

ID: 558407.0, MPI für Neurobiologie / Axonal Growth and Regeneration
Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury
Authors:Hellal, F.; Hurtado, A.; Ruschel, J.; Flynn, K. C.; Laskowski, C. J.; Umlauf, M.; Kapitein, L. C.; Strikis, D.; Lemmon, V.; Bixby, J.; Hoogenraad, C. C.; Bradke, F.
Date of Publication (YYYY-MM-DD):2011-02-18
Title of Journal:Science
Journal Abbrev.:Science
Issue / Number:6019
Start Page:928
End Page:931
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. These processes are tightly regulated by microtubule dynamics. Here, moderate microtubule stabilization decreased scar formation after spinal cord injury in rodents through various cellular mechanisms, including dampening of transforming growth factor-beta signaling. It prevented accumulation of chondroitin sulfate proteoglycans and rendered the lesion site permissive for axon regeneration of growth-competent sensory neurons. Microtubule stabilization also promoted growth of central nervous system axons of the Raphe-spinal tract and led to functional improvement. Thus, microtubule stabilization reduces fibrotic scarring and enhances the capacity of axons to grow.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Affiliations:MPI für Neurobiologie/Axonal Growth and Regeneration (Bradke)
External Affiliations:[Hurtado, Andres] Johns Hopkins Univ, Hugo W Moser Res Inst Kennedy Krieger, Int Ctr Spinal Cord Injury, Dept Neurol, Baltimore, MD 21205 USA.; [Kapitein, Lukas C.; Hoogenraad, Casper C.] Erasmus MC, Dept Neurosci, NL-3000 CA Rotterdam, Netherlands.; [Kapitein, Lukas C.; Hoogenraad, Casper C.] Univ Utrecht, Fac Sci, NL-3584 CH Utrecht, Netherlands.; [Strikis, Dinara; Lemmon, Vance; Bixby, John] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL 33136 USA.
Identifiers:ISI:000287455100062 [ID No:1]
ISSN:0036-8075 [ID No:2]
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