Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für Neurobiologie     Collection: Axonal Growth and Regeneration     Display Documents



  history
ID: 558407.0, MPI für Neurobiologie / Axonal Growth and Regeneration
Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury
Authors:Hellal, F.; Hurtado, A.; Ruschel, J.; Flynn, K. C.; Laskowski, C. J.; Umlauf, M.; Kapitein, L. C.; Strikis, D.; Lemmon, V.; Bixby, J.; Hoogenraad, C. C.; Bradke, F.
Language:English
Date of Publication (YYYY-MM-DD):2011-02-18
Title of Journal:Science
Journal Abbrev.:Science
Volume:331
Issue / Number:6019
Start Page:928
End Page:931
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. These processes are tightly regulated by microtubule dynamics. Here, moderate microtubule stabilization decreased scar formation after spinal cord injury in rodents through various cellular mechanisms, including dampening of transforming growth factor-beta signaling. It prevented accumulation of chondroitin sulfate proteoglycans and rendered the lesion site permissive for axon regeneration of growth-competent sensory neurons. Microtubule stabilization also promoted growth of central nervous system axons of the Raphe-spinal tract and led to functional improvement. Thus, microtubule stabilization reduces fibrotic scarring and enhances the capacity of axons to grow.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Affiliations:MPI für Neurobiologie/Axonal Growth and Regeneration (Bradke)
External Affiliations:[Hurtado, Andres] Johns Hopkins Univ, Hugo W Moser Res Inst Kennedy Krieger, Int Ctr Spinal Cord Injury, Dept Neurol, Baltimore, MD 21205 USA.; [Kapitein, Lukas C.; Hoogenraad, Casper C.] Erasmus MC, Dept Neurosci, NL-3000 CA Rotterdam, Netherlands.; [Kapitein, Lukas C.; Hoogenraad, Casper C.] Univ Utrecht, Fac Sci, NL-3584 CH Utrecht, Netherlands.; [Strikis, Dinara; Lemmon, Vance; Bixby, John] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL 33136 USA.
Identifiers:ISI:000287455100062 [ID No:1]
ISSN:0036-8075 [ID No:2]
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.