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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Publikationen des W. G. Kerckhoff-Instituts     Display Documents



ID: 559568.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Publikationen des W. G. Kerckhoff-Instituts
A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system
Authors:Zielonka, M.; Xia, J.; Friedel, R. H.; Offermanns, S.; Worzfeld, T.
Title of Journal:Exp Cell Res
Volume:316
Issue / Number:15
Start Page:2477
End Page:86
Audience:Not Specified
Abstract / Description:Plexins serve as receptors for semaphorins and play important roles in the developing nervous system. Plexin-B2 controls decisive developmental programs in the neural tube and cerebellum. However, whether Plexin-B2 also regulates biological functions in adult nonneuronal tissues is unknown. Here we show by two methodologically independent approaches that Plexin-B2 is expressed in discrete cell types of several nonneuronal tissues in the adult mouse. In the vasculature, Plexin-B2 is selectively expressed in functionally specialized endothelial cells. In endocrine organs, Plexin-B2 localizes to the pancreatic islets of Langerhans and to both cortex and medulla of the adrenal gland. Plexin-B2 expression is also detected in certain types of immune and epithelial cells. In addition, we report on a systematic comparison of the expression patterns of Plexin-B2 and its ligand Sema4C, which show complementarity or overlap in some but not all tissues. Furthermore, we demonstrate that Plexin-B2 and its family member Plexin-B1 display largely nonredundant expression patterns. This work establishes Plexin-B2 and Sema4C as potential regulators of the vascular and endocrine system and provides an anatomical basis to understand the biological functions of this ligand-receptor pair.
Free Keywords:Animals; Blood Vessels/embryology/*metabolism; Embryo, Mammalian; Endocrine System/embryology/*metabolism; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Reporter; Ligands; Mice; Mice, Transgenic; Neovascularization, Physiologic/genetics/physiology; Nerve Tissue Proteins/*genetics/metabolism/*physiology; Promoter Regions, Genetic/physiology; Receptors, Cell Surface/genetics/metabolism; Respiratory System/embryology/metabolism; Semaphorins/genetics/metabolism/*physiology; beta-Galactosidase/genetics/metabolism
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:Max-Planck-Institute for Heart and Lung Research, Department of Pharmacology, Ludwigstr. 43, 61231 Bad Nauheim, Germany.
Identifiers:ISSN:1090-2422 (Electronic) 0014-4827 (Linking)
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=..
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