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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Publikationen des W. G. Kerckhoff-Instituts     Display Documents

ID: 559809.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Publikationen des W. G. Kerckhoff-Instituts
Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesis
Authors:Hirschberg, A.; Deng, S.; Korostylev, A.; Paldy, E.; Costa, M. R.; Worzfeld, T.; Vodrazka, P.; Wizenmann, A.; Gotz, M.; Offermanns, S.; Kuner, R.
Title of Journal:Mol Cell Biol
Issue / Number:3
Start Page:764
End Page:80
Audience:Not Specified
Abstract / Description:Semaphorins and their receptors, plexins, are emerging as key regulators of various aspects of neural and nonneural development. Semaphorin 4D (Sema4D) and B-type plexins demonstrate distinct expression patterns over critical time windows during the development of the murine neocortex. Here, analysis of mice genetically lacking plexin-B1 or plexin-B2 revealed the significance of Sema4D-plexin-B signaling in cortical development. Deficiency of plexin-B2 resulted in abnormal cortical layering and defective migration and differentiation of several subtypes of cortical neurons, including Cajal-Retzius cells, GABAergic interneurons, and principal cells in vivo. In contrast, a lack of plexin-B1 did not impact on cortical development in vivo. In various ex vivo assays on embryonic forebrain, Sema4D enhanced the radial and tangential migration of developing neurons in a plexin-B2-dependent manner. These results suggest that Sema4D-plexin-B2 interactions regulate mechanisms underlying cell specification, differentiation, and migration during corticogenesis.
Free Keywords:Animals; Cell Movement/genetics/physiology; Gene Expression Regulation, Developmental; Mice; Mice, Knockout; Mutation/genetics/physiology; Neocortex/cytology/*embryology/metabolism; Nerve Tissue Proteins/genetics/*metabolism; Neurons/cytology/*metabolism; Receptors, Cell Surface/genetics/*metabolism; Semaphorins/*metabolism; Sequence Deletion/genetics/physiology
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
Identifiers:ISSN:1098-5549 (Electronic) 0270-7306 (Linking)
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