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          Institute: MPI für Neurobiologie     Collection: Behavioral Genetics     Display Documents



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ID: 561301.0, MPI für Neurobiologie / Behavioral Genetics
Bruchpilot, A Synaptic Active Zone Protein for Anesthesia-Resistant Memory
Authors:Knapek, S.; Sigrist, S.; Tanimoto, H.
Language:English
Date of Publication (YYYY-MM-DD):2011-03-02
Title of Journal:Journal of Neuroscience
Journal Abbrev.:J. Neurosci.
Volume:31
Issue / Number:9
Start Page:3453
End Page:3458
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:In Drosophila, aversive associative memory of an odor consists of heterogeneous components with different stabilities. Here we report that Bruchpilot (Brp), a ubiquitous presynaptic active zone protein, is required for olfactory memory. Brp was shown before to facilitate efficient vesicle release, particularly at low stimulation frequencies. Transgenic knockdown in the Kenyon cells of the mushroom body, the second-order olfactory interneurons, revealed that Brp is required for olfactory memory. We further demonstrate that Brp in the Kenyon cells preferentially functions for anesthesia-resistant memory. Another presynaptic protein, Synapsin, was shown previously to be required selectively for the labile anesthesia-sensitive memory, which is less affected in brp knockdown. Thus, consolidated and labile components of aversive olfactory memory can be dissociated by the function of different presynaptic proteins.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Annegret Cerny
Affiliations:MPI für Neurobiologie/Behavioral Genetics (Tanimoto)
External Affiliations:[Sigrist, Stephan] Univ Würzburg, Rudolf Virchow Zentrum, Deutsch Forsch Gemeinschaft, Forschungszentrum Expt Biomed, D-97078 Würzburg, Germany.; [Sigrist, Stephan] Free Univ Berlin, Fachbereich Biol Chem Pharm, Inst Biol Genet, D-14195 Berlin, Germany.
Identifiers:ISI:000288055200034 [ID No:1]
ISSN:0270-6474 [ID No:2]
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