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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 6 - Molecular Biology (D. Weigel)     Display Documents

ID: 561630.0, MPI für Entwicklungsbiologie / Abteilung 6 - Molecular Biology (D. Weigel)
The Scale of Population Structure in Arabidopsis thaliana
Authors:Platt, A.; Horton, M.; Huang, Y. S.; Li, Y.; Anastasio, A. E.; Mulyati, N. W.; Agren, J.; Bossdorf, O.; Byers, D.; Donohue, K.; Dunning, M.; Holub, E. B.; Hudson, A.; Le Corre, V.; Loudet, O.; Roux, F.; Warthmann, N.; Weigel, D.; Rivero, L.; Scholl, R.; Nordborg, M.; Bergelson, J.; Borevitz, J. O.
Date of Publication (YYYY-MM-DD):2010-02
Title of Journal:PLoS Genetics
Issue / Number:2
Sequence Number of Article:1000843
Review Status:not specified
Audience:Not Specified
Abstract / Description:The population structure of an organism reflects its evolutionary history and influences its evolutionary trajectory. It constrains the combination of genetic diversity and reveals patterns of past gene flow. Understanding it is a prerequisite for detecting genomic regions under selection, predicting the effect of population disturbances, or modeling gene flow. This paper examines the detailed global population structure of Arabidopsis thaliana. Using a set of 5,707 plants collected from around the globe and genotyped at 149 SNPs, we show that while A. thaliana as a species self-fertilizes 97% of the time, there is considerable variation among local groups. This level of outcrossing greatly limits observed heterozygosity but is sufficient to generate considerable local haplotypic diversity. We also find that in its native Eurasian range A. thaliana exhibits continuous isolation by distance at every geographic scale without natural breaks corresponding to classical notions of populations. By contrast, in North America, where it exists as an exotic species, A. thaliana exhibits little or no population structure at a continental scale but local isolation by distance that extends hundreds of km. This suggests a pattern for the development of isolation by distance that can establish itself shortly after an organism fills a new habitat range. It also raises questions about the general applicability of many standard population genetics models. Any model based on discrete clusters of interchangeable individuals will be an uneasy fit to organisms like A. thaliana which exhibit continuous isolation by distance on many scales.
Free Keywords:landscape genetics; divergence; humans; model; size
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 6 - Molekulare Biologie (Detlef Weigel)
External Affiliations:Univ So Calif, Los Angeles, CA 90089 USA Univ So Calif, Los Angeles, CA 90089 USA Univ So Calif, Los Angeles, CA 90089 USA Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA Uppsala Univ, Dept Ecol & Evolut, Uppsala, Sweden Univ Bern, Inst Plant Sci, Bern, Switzerland Illinois State Univ, Sch Biol Sci, Normal, IL 61761 USA Duke Univ, Dept Biol, Durham, NC USA Univ Warwick, Wellesbourne, Warwick, England Univ Edinburgh, Inst Plant Mol Sci, Edinburgh, Midlothian, Scotland UMR Biol & Gest Adventices, Dijon, France Inst Jean Pierre Bourgin, INRA, Versailles, France Univ Lille, Lab Genet & Evolut Populat Vegetales, Villeneuve Dascq, France Max Planck Inst Dev Biol, Dept Mol Biol, Tubingen, Germany Ohio State Univ, Arabidopsis Biol Resource Ctr, Columbus, OH 43210 USA Gregor Mendel Inst, Vienna, Austria %G English
Identifiers:ISSN:1553-7390 %R ARTN e1000843 DOI 10.1371/journal.pge... [ID No:1]
ISI:000275262700023 [ID No:2]
ISI:000275262700023 [ID No:3]
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