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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 6 - Molecular Biology (D. Weigel)     Display Documents

ID: 561633.0, MPI für Entwicklungsbiologie / Abteilung 6 - Molecular Biology (D. Weigel)
Natural Diversity in Flowering Responses of Arabidopsis thaliana Caused by Variation in a Tandem Gene Array
Authors:Rosloski, S. M.; Jali, S. S.; Balasubramanian, S.; Weigel, D.; Grbic, V.
Date of Publication (YYYY-MM-DD):2010-09
Title of Journal:Genetics
Issue / Number:1
Start Page:263
End Page:276
Review Status:not specified
Audience:Not Specified
Abstract / Description:Tandemly arrayed genes that belong to gene families characterize genomes of many organisms. Gene duplication and subsequent relaxation of selection can lead to the establishment of paralogous cluster members that may evolve along different trajectories. Here, we report on the structural variation in MADS AFFECTING FLOWERING 2 (MAF2) gene, one member of the tandemly duplicated cluster of MADS-box-containing transcription factors in Arabidopsis thaliana. The altered gene structure at the MAF2 locus is present as a moderate-frequency polymorphism in Arabidopsis and leads to the extensive diversity in transcript patterns due to alternative splicing. Rearrangements at the MAF2 locus are associated with an early flowering phenotype in BC5 lines. The lack of suppression of flowering time in a MAF2-insertion line expressing the MAF2-specific artificial miRNA suggests that these MAF2 variants are behaving as loss-of-function alleles. The variation in gene architecture is also associated with segregation distortion, which may have facilitated the spread and the establishment of the corresponding alleles throughout the Eurasian range of the A. thaliana population.
Free Keywords:quantitative trait loci; disease resistance genes; inbred line populations; unequal crossing-over; time genes; protein families; DNA-sequence; copy-number; genomic DNA; a-thaliana
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 6 - Molekulare Biologie (Detlef Weigel)
External Affiliations:Univ Western Ontario, Dept Biol, 1151 Richmond St, London, ON N6A 5B8, Canada Univ Western Ontario, Dept Biol, 1151 Richmond St, London, ON N6A 5B8, Canada Univ Western Ontario, Dept Biol, London, ON N6A 5B8, Canada Max Planck Inst Dev Biol, Dept Mol Biol, D-72076 Tubingen, Germany Univ Queensland, Sch Biol Sci, St Lucia, Qld 4072, Australia %G English
Identifiers:ISSN:0016-6731 %R DOI 10.1534/genetics.110.116392 [ID No:1]
ISI:000281950600022 [ID No:2]
ISI:000281950600022 [ID No:3]
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