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ID: 563248.0, MPI für Neurobiologie / Neuroimmunology
Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin
Authors:Obermeier, B.; Lovato, L.; Mentele, R.; Bruck, W.; Forne, I.; Imhof, A.; Lottspeich, F.; Turk, K. W.; Willis, S. N.; Wekerle, H.; Hohlfeld, R.; Hafler, D. A.; O'Connor, K. C.; Dornmair, K.
Date of Publication (YYYY-MM-DD):2011-04
Title of Journal:Journal of Neuroimmunology
Journal Abbrev.:J. Neuroimmunol.
Issue / Number:1-2
Start Page:245
End Page:248
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the transcriptomes of both, brain lesions and CSF, providing evidence for a strong overlap of the IgG repertoires in brain lesions and in the CSF. (C) 2011 Elsevier B.V. All rights reserved.
Free Keywords:Multiple sclerosis; B cells; Cerebrospinal fluid; Central nervous system; Oligoclonal bands
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Affiliations:MPI für Neurobiologie/Neuroimmunology (Wekerle)
MPI für Neurobiologie/Neuroimmunology (Wekerle)/Clinical Neuroimmunology (Hohlfeld)
External Affiliations:[Lovato, Laura; Willis, Simon N.] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA.; [Lovato, Laura; Willis, Simon N.] Brigham & Womens Hosp, Dept Neurol, Ctr Neurol Dis, Boston, MA 02115 USA.; [Mentele, Reinhard; Lottspeich, Friedrich] Max Planck Inst Biochem, Dept Prot Analyt, D-82152 Martinsried, Germany.; [Brueck, Wolfgang] Univ Med Ctr, Dept Neuropathol, D-37075 Gottingen, Germany.; [Forne, Ignasi; Imhof, Axel] Univ Munich, Lab Prot Analyt, D-80336 Munich, Germany.; [Turk, Katherine W.] Tufts Univ, Sch Med, Boston, MA 02115 USA.; [Hafler, David A.; O'Connor, Kevin C.] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA.
Identifiers:ISI:000290070000033 [ID No:1]
ISSN:0165-5728 [ID No:2]
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