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          Institute: MPI für Psychiatrie     Collection: Publikationen MPI für Psychiatrie     Display Documents



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ID: 563625.0, MPI für Psychiatrie / Publikationen MPI für Psychiatrie
Feeble awake effects of plasminogen activator inhibitor type-1 in mice
Authors:Sakakibara, H.; Romanowski, C. P. N.; Jakubcakova, V.; Flachskamm, C.; Shimoi, K.; Kimura, M.
Language:English
Date of Publication (YYYY-MM-DD):2011-07-07
Title of Journal:Behavioural Brain Research
Volume:220
Issue / Number:2
Start Page:354
End Page:357
Review Status:not specified
Audience:Not Specified
Abstract / Description:Plasminogen activator inhibitor-type 1 (PAI-1) is involved in the fibrinolytic system and shows its increased levels in diseases, e.g., obesity and sleep apnea syndrome. The aim of the study is to investigate whether PAI-1 affects sleep-wake patterns in mice. When recombinant mouse PAI-1 was administered intraperitoneally, only rapid but short increases in time spent awake were observed after 20 or 100 mu g/kg, although its plasma concentration was kept high for an hour. The results suggest that PAI-1 may serve its role rather as a marker than an initiator of disturbed sleep. (C) 2011 Elsevier B.V. All rights reserved.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:N. N.
Affiliations:MPI für Psychiatrie
Identifiers:ISI:000289958300014 [ID No:1]
ISSN:0166-4328 [ID No:2]
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