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          Institute: MPI für Polymerforschung     Collection: MPI Polymerforschung     Display Documents

ID: 56392.0, MPI für Polymerforschung / MPI Polymerforschung
64-Channel extended gate electrode arrays for extracellular signal recording
Authors:Ecken, H.; Ingebrandt, S.; Krause, M.; Richter, D.; Hara, M.; Offenhäusser, Andreas
Date of Publication (YYYY-MM-DD):2003-09-30
Title of Journal:Electrochimica Acta
Journal Abbrev.:Electrochim. Acta
Issue / Number:20-22
Start Page:3355
End Page:3362
Review Status:not specified
Audience:Not Specified
Abstract / Description:A 64-channel amplifier system for the recording of extracellular signals with planar metal microelectrodes is presented. Gold metal microelectrodes on glass wafers were fabricated using standard photolithographic techniques. The measurement system was divided into a headstage preamplifier and a main amplifier. The inherent noise of the extracellular recording system was minimized by using an independent battery supply. The metal electrodes were directly connected to the gates of low noise junction field effect transistors (JFETs) using a specially designed electronic circuit. With this set-up, it was possible to record extracellular signals with planar metal microelectrodes without any surface modification for impedance reduction. A feedback circuit in the first amplification stage compensated slow drifts of the gold microelectrodes, which made online sampling of all 64 channels with a sampling rate of 10 kHz possible. Recordings were taken from rat cardiac myocytes cultured on fibronectin coated sensor chips. The system exhibited a good signal-to-noise ratio. It was able to detect the signal propagation within the cardiac cell layer and it could be used for pharmacological investigations involving the heart, (C) 2003 Elsevier Ltd. All rights reserved.
Free Keywords:extended gate electrodes, extracellular recording, sensor array, action potential, rat cardiac myocytes
Comment of the Author/Creator:Date: 2003, SEP 30
External Publication Status:published
Document Type:Article
Affiliations:MPI für Polymerforschung
External Affiliations:Res Ctr Jülich, Inst Thin Films & Interfaces ISG2, D-52425 Jülich, Germany.; RIKEN, Frontier Res Syst, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan.
Identifiers:ISI:000185123400057 [ID No:1]
ISSN:0013-4686 [ID No:2]
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