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          Institute: MPI für medizinische Forschung     Collection: Abteilung Biophysik     Display Documents



ID: 565548.0, MPI für medizinische Forschung / Abteilung Biophysik
Derivatization of ribosomes and of tRNA with an undecagold cluster: crystallographic and functional studies
Translation of Title:Derivatization of ribosomes and of tRNA with an undecagold cluster: crystallographic and functional studies
Authors:Weinstein, S.; Jahn, Werner; Laschever, M.; Arad, T.; Tichelaar, Willem; Haider, M.; Glotz, C.; Boeckh, T.; Berkovitch−Yellin, Z.; Franceschi, F.; Yonath, A.
Language:English
Date of Publication (YYYY-MM-DD):1992-08-01
Title of Journal:Journal of Crystal Growth
Journal Abbrev.:Journal of Crystal Growth
Volume:122
Issue / Number:1
Start Page:286
End Page:292
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:An undecagold cluster was covalently attached to whole ribosomes and to their small and large subunits prior to their crystallization. X−ray crystallographic data were collected from crystals of the first two. The same cluster was bound to tRNAphe fromE. coli at base 47. It was found that the modified tRNA molecule binds to the ribosome and can be aminoacylated by its cognate synthetase. The gold cluster modified tRNAphe may be used for phasing diffraction data of crystals of complexes containing it, mimicking defined states in the process of protein biosynthesis
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Biophysik/Muskelforschung
MPI für medizinische Forschung/Abteilung Biophysik
MPI für medizinische Forschung/Abteilung Zellphysiologie
Identifiers:LOCALID:7096
URI:http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob...
URI:http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob...
DOI:10.1016%2F0022-0248%2892%2990257-J
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