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          Institute: MPI für medizinische Forschung     Collection: Abteilung Zellphysiologie     Display Documents



ID: 565911.0, MPI für medizinische Forschung / Abteilung Zellphysiologie
Cholinergic ligand−induced affinity changes in Torpedo californica acetylcholine receptor
Translation of Title:Cholinergic ligand−induced affinity changes in Torpedo californica acetylcholine receptor
Authors:Lee, T.; Witzemann, Veit; Schimerlik, M.; Raftery, Michael A.
Language:English
Date of Publication (YYYY-MM-DD):1977-09-01
Title of Journal:Archives of Biochemistry and Biophysics
Journal Abbrev.:Arch. Biochem. Biophys.
Volume:183
Issue / Number:1
Start Page:57
End Page:63
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The binding of cholinergic ligands to Torpedo californica acetylcholine receptor has been studied in vitro by inhibition of the time course of 125I−labeled α−bungarotoxin−receptor complex formation. The extent of inhibition was dependent on the duration of exposure to the ligand, the apparent affinity for ligand increasing with time, and was reversible upon removal of ligand. Ligand concentration, temperature, and Ca2+ ions influenced this effect which is reminiscent of receptor desensitization in vivo. Such effects were observed both for a cholinergic agonist, carbamylcholine, and for an antagonist, bis(3−aminopyridinium)−1,10−decane diiodide. A minimal model is discussed which can account for these effects and for receptor ligand association leading to postsynaptic depolarization
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie/Molekulare Anatomie neuromuskulärer Synapsen
MPI für medizinische Forschung/Arbeitsgruppe Witzemann / Koenen
Identifiers:LOCALID:6726
URI:http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob...
URI:http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob...
DOI:10.1016%2F0003-9861%2877%2990418-0
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