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          Institute: MPI für medizinische Forschung     Collection: Abteilung Zellphysiologie     Display Documents



ID: 565913.0, MPI für medizinische Forschung / Abteilung Zellphysiologie
Ligand−induced conformation changes in Torpedo californica membrane−bound acetylcholine receptor
Translation of Title:Ligand−induced conformation changes in Torpedo californica membrane−bound acetylcholine receptor
Authors:Quast, Ulrich; Schimerlik, M.; Lee, T.; Witzemann, Veit; Blanchard, Steven G.; Raftery, Michael A.
Language:English
Date of Publication (YYYY-MM-DD):1978-06-01
Title of Journal:Biochemistry
Journal Abbrev.:Biochem.
Volume:17
Issue / Number:12
Start Page:2405
End Page:2414
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:A time−dependent increase in ligand affinity has been studied in cholinergic ligand binding to Torpedocalifornica acetylcholine receptor by inhibition of the kinetics of of [125I]−alpha−bungarotoxin−receptor complex formation. The conversion of the acetylcholine receptor from low to high affinity form was induced by both agonists and antagonists of acetylcholine and was reversible upon removal of the ligand. The slow ligand induced affinity change in vitro resembled electrophysiological desensitization observed at the neuromuscular junction and described by a two−state model (Katz, B., & Thesleff, S. (1957) J. Physiol. 138, 63). A quantitative treatment of the rate and equilibrium constants determined for binding of the agonist carbamoylcholine to membrane bound acetylcholine receptor indicated that the two−state model is not compatible with the in vitro results
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie/Molekulare Anatomie neuromuskulärer Synapsen
MPI für medizinische Forschung/Arbeitsgruppe Witzemann / Koenen
Identifiers:LOCALID:6728
URI:http%3A%2F%2Fpubs.acs.org%2Fdoi%2Fpdf%2F10.1021%2F...
URI:http%3A%2F%2Fpubs.acs.org%2Fdoi%2Fabs%2F10.1021%2F...
DOI:10.1021%2Fbi00605a024
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