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          Institute: MPI für medizinische Forschung     Collection: Kortikale Schaltkreise     Display Documents



ID: 566030.0, MPI für medizinische Forschung / Kortikale Schaltkreise
Wiring specificity in the direction−selectivity circuit of the retina
Translation of Title:Wiring specificity in the direction−selectivity circuit of the retina
Authors:Briggman, Kevin; Helmstaedter, Moritz; Denk, Winfried
Language:English
Date of Publication (YYYY-MM-DD):2011-03-10
Title of Journal:Nature
Journal Abbrev.:Nature
Volume:471
Issue / Number:7337
Start Page:183
End Page:188
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The proper connectivity between neurons is essential for the implementation of the algorithms used in neural computations, such as the detection of directed motion by the retina. The analysis of neuronal connectivity is possible with electron microscopy, but technological limitations have impeded the acquisition of high−resolution data on a large enough scale. Here we show, using serial block−face electron microscopy and two−photon calcium imaging, that the dendrites of mouse starburst amacrine cells make highly specific synapses with direction−selective ganglion cells depending on the ganglion cell's preferred direction. Our findings indicate that a structural (wiring) asymmetry contributes to the computation of direction selectivity. The nature of this asymmetry supports some models of direction selectivity and rules out others. It also puts constraints on the developmental mechanisms behind the formation of synaptic connections. Our study demonstrates how otherwise intractable neurobiological questions can be addressed by combining functional imaging with the analysis of neuronal connectivity using large−scale electron microscopy
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie
MPI für medizinische Forschung/Abteilung Biomedizinische Optik
MPI für medizinische Forschung/Abteilung Zellphysiologie/Kortikale Schaltkreise
MPI für medizinische Forschung/Abteilung Biomedizinische Optik/Gruppe Moritz Helmstaedter
Identifiers:LOCALID:7669
URI:http%3A%2F%2Fwww.nature.com%2Fnature%2Fjournal%2Fv...
URI:http%3A%2F%2Fwww.nature.com%2Fnature%2Fjournal%2Fv...
DOI:10.1038%2Fnature09818
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