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          Institute: MPI für medizinische Forschung     Collection: Olfaction Web     Display Documents



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ID: 566187.0, MPI für medizinische Forschung / Olfaction Web
Impaired associative fear learning in mice with complete loss or haploinsufficiency of AMPA GluR1 receptors
Translation of Title:Impaired associative fear learning in mice with complete loss or haploinsufficiency of AMPA GluR1 receptors
Authors:Feyder, Michael; Wiedholz, Lisa M.; Sprengel, Rolf; Holmes, Andrew
Language:English
Date of Publication (YYYY-MM-DD):2007-10-01
Title of Journal:Frontiers in Behavioural Neuroscience
Journal Abbrev.:Frontiers in behavioural neuroscience
Volume:1
Issue / Number:4
Start Page:1
End Page:5
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:There is compelling evidence that L−alpha−amino−3−hydroxy−5−methylisoxazole−4−propionate (AMPA) glutamate receptors containing the GluR1 subunit contribute to the molecular mechanisms associated with learning. AMPA GluR1 glutamate receptor knockout mice (KO) exhibit abnormal hippocampal and amygdala plasticity, and deficits on various assays for cognition including Pavlovian fear conditioning. Here we examined associative fear learning in mice with complete absence (KO) or partial loss (heterozygous mutant, HET) of GluR1 on multiple fear conditioning paradigms. After multi−trial delay or trace conditioning, KO displayed impaired tone and context fear recall relative to WT, whereas HET were normal. After one−trial delay conditioning, both KO and HET showed impaired tone and context recall. HET and KO showed normal nociceptive sensitivity in the hot plate and tail flick tests. These data demonstrate that the complete absence of GluR1 subunit−containing receptors prevents the formation of associative fear memories, while GluR1 haploinsufficiency is sufficient to impair one−trial fear learning. These findings support growing evidence of a major role for GluR1−containing AMPA receptors in amygdalamediated forms of learning and memory
Free Keywords:glutamate; learning; GluRl; AMPA; mouse
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie/Olfaction Web
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Rolf Sprengel
Identifiers:LOCALID:7237
URI:http%3A%2F%2Ffrontiersin.org%2Fbehavioralneuroscie...
URI:http%3A%2F%2Fwww.frontiersin.org%2Fbehavioral_neur...
URI:http%3A%2F%2Ffrontiersin.org%2Fbehavioralneuroscie...
DOI:10.3389%2Fneuro.08.004.2007
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