Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für medizinische Forschung     Collection: Olfaction Web     Display Documents



ID: 566190.0, MPI für medizinische Forschung / Olfaction Web
Targeted Deletion of the GluR−1 AMPA Receptor in Mice Dissociates
General and Outcome−Specific Influences of Appetitive Rewards on
Learning
Translation of Title:Targeted Deletion of the GluR−1 AMPA Receptor in Mice Dissociates
General and Outcome−Specific Influences of Appetitive Rewards on
Learning
Authors:Johnson, Alexander W.; Bannerman, David M.; Rawlins, John Nicholas P.; Sprengel, Rolf; Good, Mark A.
Language:English
Date of Publication (YYYY-MM-DD):2007-12-01
Title of Journal:Behav. Neurosci.
Journal Abbrev.:Behav. Neurosci.
Volume:121
Issue / Number:6
Start Page:1192
End Page:1202
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The authors assessed the hypothesis that deletion of the GluR−1 subtype of the alpha−amino−3−hydroxy−
5−methyl−4−isoxazole propionate (AMPA) receptor in mice disrupts the associative activation of a
sensory−specific representation of an appetitive reward. In Experiment 1, mice received training on a
Pavlovian−instrumental transfer task. In the test stage, conditioned stimulus (CS) presentations enhanced
instrumental actions in both groups. However, this effect was specific to the action that shared the same
outcome as the CS in wild−type (WT), but not GluR−1/, mice. In Experiment 2, the mice were trained
on a heterogeneous instrumental chain in which rewards were obtained for emitting 1 response (R1, that
was distal to reward delivery), followed by a 2nd response (R2, that was proximal to reward delivery).
A change in general motivational state (from hungry to sated) reduced the number of R2 responses in
both groups. In contrast, an outcome−specific satiety treatment produced a selective decline in R1
responding only in WT mice. The results support the hypothesis that GluR−1 deletion impairs the
associative activation of a representation of the sensory−specific incentive motivational properties of an
appetitive reward
Free Keywords:AMPA, receptor, motivation, mouse, amygdala
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie/Olfaction Web
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Rolf Sprengel
Identifiers:LOCALID:7596
URI:http%3A%2F%2Fpsycnet.apa.org%2Fjournals%2Fbne%2F12...
URI:http%3A%2F%2Fpsycnet.apa.org%2Fjournals%2Fbne%2F12...
URI:http%3A%2F%2Fpsycnet.apa.org%2Fjournals%2Fbne%2F12...
DOI:10.1037%2F0735-7044.121.6.1192
Full Text:
Sorry, no privileges
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.