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          Institute: MPI für medizinische Forschung     Collection: Olfaction Web     Display Documents



ID: 566198.0, MPI für medizinische Forschung / Olfaction Web
Deletion of the GluA1 AMPA receptor subunit alters
the expression of short−term memory
Translation of Title:Deletion of the GluA1 AMPA receptor subunit alters
the expression of short−term memory
Authors:Sanderson, David J.; Sprengel, Rolf; Seeburg, Peter H.; Bannerman, David M.
Language:English
Date of Publication (YYYY-MM-DD):2011-02-16
Title of Journal:Learning & Memory
Journal Abbrev.:Learning & Memory
Volume:18
Issue / Number:3
Start Page:128
End Page:131
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Deletion of the GluA1 AMPA receptor subunit selectively impairs short−term memory for spatial locations. We further
investigated this deficit by examining memory for discrete nonspatial visual stimuli in an operant chamber.
Unconditioned suppression of magazine responding to visual stimuli was measured in wild−type and GluA1 knockout
mice. Wild−type mice showed less suppression to a stimulus that had been presented recently than to a stimulus that had
not. GluA1 knockout mice, however, showed greater suppression to a recent stimulus than to a nonrecent stimulus.
Thus, GluA1 is not necessary for encoding, but affects the way that short−term memory is expressed
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie/Olfaction Web
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Rolf Sprengel
Identifiers:LOCALID:7659
URI:http%3A%2F%2Fintl.learnmem.org%2Fcontent%2F18%2F3%...
URI:http%3A%2F%2Fintl.learnmem.org%2Fcontent%2F18%2F3%...
URI:http%3A%2F%2Fintl.learnmem.org%2Fcontent%2F18%2F3%...
DOI:10.1101%2Flm.2014911
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