Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 566703.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Tad1p, a yeast tRNA−specific adenosine deaminase, is related to the mammalian pre−mRNA editing enzymes ADAR1 and ADAR2
Translation of Title:Tad1p, a yeast tRNA−specific adenosine deaminase, is related to the mammalian pre−mRNA editing enzymes ADAR1 and ADAR2
Authors:Gerber, A.; Grosjean, H.; Melcher, Thorsten; Keller, Walter
Language:English
Date of Publication (YYYY-MM-DD):1998-08-01
Title of Journal:EMBO Journal
Journal Abbrev.:EMBO J.
Volume:17
Issue / Number:16
Start Page:4780
End Page:4789
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:We have identified an RNA−specific adenosine deaminase (termed Tad1p/scADAT1) from Saccharomyces cerevisiae that selectively converts adenosine at position 37 of eukaryotic tRNAAla to inosine. The activity of purified recombinant Tad1p depends on the conformation of its tRNA substrate and the enzyme was found to be inactive on all other types of RNA tested. Mutant strains in which the TAD1 gene is disrupted are viable but lack Tad1p enzyme activity and their tRNAAla is not modified at position A37. Transformation of the mutant cells with the TAD1 gene restored enzyme activity. Tad1p has significant sequence similarity with the mammalian editing enzymes which act on specific precursor−mRNAs and on long double−stranded RNA. These findings suggest an evolutionary link between pre−mRNA editing and tRNA modification
Free Keywords:adenosine deaminase; inosine; RNA editing; tRNAAla; yeast
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
Relations:Has References-URI:http%3A%2F%2Fchemport.cas.org%2Fcgi-bin%2Fsdcgi%3FAPP%3Dftslink%26action%3Dreflink%26origin%3Dnpg%26version%3D1.0%26coi%3D1%3ACAS%3A528%3ADyaL28XotlSjsA%253D%253D%26pissn%3D0261-4189%26pyear%3D1998%26md5%3Db812453d964d71d2df5dfd81b088b218
Has References-URI:http%3A%2F%2Fchemport.cas.org%2Fcgi-bin%2Fsdcgi%3FAPP%3Dftslink%26action%3Dreflink%26origin%3Dnpg%26version%3D1.0%26coi%3D1%3ASTN%3A280%3AByiA3snhtVU%253D%26pissn%3D0261-4189%26pyear%3D1998%26md5%3Dbceca12a7fdb909d2ba98ef7ef9e72b0
Has References-URI:http%3A%2F%2Fchemport.cas.org%2Fcgi-bin%2Fsdcgi%3FAPP%3Dftslink%26action%3Dreflink%26origin%3Dnpg%26version%3D1.0%26coi%3D1%3ACAS%3A528%3ADyaK2MXhtVSju7zJ%26pissn%3D0261-4189%26pyear%3D1998%26md5%3Db5b6b1eea53a4d18067094e56815b24a
Has References-URI:http%3A%2F%2Fchemport.cas.org%2Fcgi-bin%2Fsdcgi%3FAPP%3Dftslink%26action%3Dreflink%26origin%3Dnpg%26version%3D1.0%26coi%3D1%3ACAS%3A528%3ADyaK2MXkvFemtbc%253D%26pissn%3D0261-4189%26pyear%3D1998%26md5%3D6213ae01779ff71b03f0b687a81e5ae4
Has References-URI:http%3A%2F%2Fchemport.cas.org%2Fcgi-bin%2Fsdcgi%3FAPP%3Dftslink%26action%3Dreflink%26origin%3Dnpg%26version%3D1.0%26coi%3D1%3ACAS%3A528%3ADyaK28XisVShtw%253D%253D%26pissn%3D0261-4189%26pyear%3D1998%26md5%3De04efcfe7d1a337ff5f4371f06e1397e
Identifiers:LOCALID:6171
URI:http%3A%2F%2Femboj.oupjournals.org%2Fcgi%2Freprint...
URI:http%3A%2F%2Femboj.oupjournals.org%2Fcgi%2Fcontent...
URI:http%3A%2F%2Femboj.oupjournals.org%2Fcgi%2Fcontent...
Full Text:
Sorry, no privileges
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.