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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 566709.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Role of heteromer formation in GABAB receptor function
Translation of Title:Role of heteromer formation in GABAB receptor function
Authors:Kuner, Rohini; Köhr, Georg; Grünewald, Sabine; Eisenhardt, G.; Bach, Alfred W. J.; Kornau, Hans Christian
Language:English
Date of Publication (YYYY-MM-DD):1999-01-01
Title of Journal:Science
Journal Abbrev.:Science
Volume:283
Issue / Number:5398
Start Page:74
End Page:77
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Recently, GBR1, a seven−transmembrane domain protein with high affinity for gamma −aminobutyric acid (GABA)B receptor antagonists, was identified. Here, a GBR1−related protein, GBR2, was shown to be coexpressed with GBR1 in many brain regions and to interact with it through a short domain in the carboxyl−terminal cytoplasmic tail. Heterologously expressed GBR2 mediated inhibition of adenylyl cyclase; however, inwardly rectifying potassium channels were activated by GABAB receptor agonists only upon coexpression with GBR1 and GBR2. Thus, the interaction of these receptors appears to be crucial for important physiological effects of GABA and provides a mechanism in receptor signaling pathways that involve a heterotrimeric GTP−binding protein
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Georg Köhr
Identifiers:LOCALID:6408
URI:http%3A%2F%2Fwww.sciencemag.org%2Fcgi%2Freprint%2F...
URI:http%3A%2F%2Fwww.sciencemag.org%2Fcgi%2Fcontent%2F...
URI:http%3A%2F%2Fwww.sciencemag.org%2Fcgi%2Fcontent%2F...
DOI:10.1126%2Fscience.283.5398.74
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