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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 566730.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Neuroimmunoendocrine interaction in the pathogenesis of chronic heart failure
Translation of Title:Neuroimmunoendocrine interaction in the pathogenesis of chronic heart failure
Authors:Poskrebysheva, A. S.; Grinevich, Valery; Smurova, Iu. V.; Shostak, N. A.; Akmayev, Ildar G.
Language:English
Date of Publication (YYYY-MM-DD):2003-07-01
Title of Journal:Adv. Physiol. Sci.
Journal Abbrev.:Adv. Physiol. Sci.
Volume:34
Start Page:3
End Page:20
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Chronic heart failure (CHF) is a common complication of patients with heart dysfunction and of those suffering from various chronic illnesses. Although recently developed therapies revolutionized treatment of CHF, life expectancy of the survivors is still significantly reduced. Proposed neurohoromonal approach in CHF treatment is on the whole rather unsatisfactory. Recently the interest of clinical investigators has been focused on immune mechanisms in the pathogenesis of CHF. In this review we tried to summarize data concerning contribution of inflammatory cytokines to pathogenesis of CHF. The source and site of action of pro− and antiinflammatory cytokines and number of interactions among cytokines and neuroendocrine systems under CHF are considered. Finally we discuss novel therapies managing correction of both immune and neurohormonal status of the patient
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Pavel Osten
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Valery Grinevich
Identifiers:LOCALID:7358
URI:http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F12942...
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