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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 566780.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Mice with genetically altered glutamate receptors as models of schizophrenia:
A comprehensive review
Translation of Title:Mice with genetically altered glutamate receptors as models of schizophrenia:
A comprehensive review
Authors:Inta, Dragos; Monyer, Hannah; Sprengel, Rolf; Meyer−Lindenberg, Andreas; Gass, Peter
Language:English
Date of Publication (YYYY-MM-DD):2010-03-01
Title of Journal:Neuroscience & Biobehavioral Reviews
Journal Abbrev.:Neuroscience & Biobehavioral Reviews
Volume:34
Issue / Number:3
Start Page:285
End Page:294
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Recent clinical evidence for the effectiveness of new antipsychotic drugs that specifically target
glutamate receptors has rekindled interest in the glutamatergic system regarding pathophysiology and
treatment of schizophrenia. The glutamatergic hypothesis of schizophrenia was triggered by the clinical/
behavioural observation that NMDA receptor antagonists can induce psychosis in humans and abnormal
behaviour with schizophrenia−like symptoms in animals. Initial models focused on NMDA receptor
hypofunction as a potential pathogenetic mechanism. More recent genetic and pharmacological studies
revealed that malfunction of other components of the glutamatergic system might also be relevant in
explaining specific symptoms of this complex disease. Here, we review mutant mouse models with
relevance for schizophrenia. These rodent models, in which specific glutamate receptor subtypes or
various components of their intracellular transduction machinery are genetically altered, permit a
detailed dissection of the contribution of different components of the glutamate system in inducing
schizophrenia−like behaviours. They may provide insight into the pathophysiology of schizophrenia and
prove useful in the development of new therapeutics
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie/Olfaction Web
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Rolf Sprengel
Identifiers:LOCALID:7528
URI:http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob...
URI:http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob...
DOI:10.1016%2Fj.neubiorev.2009.07.010
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