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          Institute: MPI für medizinische Forschung     Collection: Gruppe Valery Grinevich     Display Documents

ID: 567063.0, MPI für medizinische Forschung / Gruppe Valery Grinevich
Cellular mechanisms of motor control in the vibrissal system
Translation of Title:Cellular mechanisms of motor control in the vibrissal system
Authors:Brecht, Michael; Grinevich, Valery; Jin, Tae−Eun; Margrie, Troy W.; Osten, Pavel
Date of Publication (YYYY-MM-DD):2006-05-31
Title of Journal:Eur. J. Physiol.
Journal Abbrev.:Eur. J. Physiol.
Issue / Number:3
Start Page:269
End Page:281
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:In this article we discuss the experimental advantages that the vibrissal motor system offers for analysis of motor control and the specializations of this system related to the unique characteristics of whisker movements. Whisker movements are often rhythmic, fast, and bilateral. Movements of individual whiskers have simple characteristics, whereas, movements of the entire vibrissae array are complex and sophisticated. In the last few years, powerful methods for high precision tracking of whisker movements have become available. The whisker musculature is arranged to permit forward movements of individual whiskers and consists−depending on the species−mainly or exclusively of fast contracting, fast fatigable muscle fibers. Whisker motor neurons are located in the lateral facial nucleus and their cellular properties might contribute to the rhythmicity of whisking. Numerous structures provide input to the lateral facial nucleus, the most mysterious and important one being the putative central pattern generator (CPG). Although recent studies identified candidate structures for the CPG, the precise identity and the functional organization of this structure remains uncertain. The vibrissa motor cortex (VMC) is the largest motor representation in the rodent brain, and recent work has clarified its localization, subdivisions, cytoarchitectonics, and connectivity. Single−cell stimulation experiments in VMC allow determining the cellular basis of cortical motor control with unprecedented precision. The functional significance of whisker movements remains to be determined
Free Keywords:Vibrissa motor cortex; Whisker tracking; Whole−cell recording; Single−cell stimulation; Whisker; Facial nucleus
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie/Whisker Representation
MPI für medizinische Forschung/Max-Planck-Forschungsgruppe Neurophysiologie des Verhaltens (Andreas T. Schaefer)
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Pavel Osten
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Valery Grinevich
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