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          Institute: MPI für medizinische Forschung     Collection: Abteilung Biomedizinische Optik     Display Documents



ID: 567346.0, MPI für medizinische Forschung / Abteilung Biomedizinische Optik
Principles governing recruitment of motoneurons during swimming in zebrafish
Translation of Title:Principles governing recruitment of motoneurons during swimming in zebrafish
Authors:Gabriel, Jens Peter; Ausborn, Jessica; Ampatzis, Konstantinos; Mahmood, Riyadh; Eklöf−Ljunggren, Emma; El Manira, Abdeljabbar
Language:English
Date of Publication (YYYY-MM-DD):2011-01-01
Title of Journal:Nature Neuroscience
Journal Abbrev.:Nat. Neurosci.
Volume:14
Issue / Number:1
Start Page:93
End Page:99
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Locomotor movements are coordinated by a network of neurons that produces sequential muscle activation. Different motoneurons need to be recruited in an orderly manner to generate movement with appropriate speed and force. However, the mechanisms governing recruitment order have not been fully clarified. Using an in vitro juvenile/adult zebrafish brainstem−spinal cord preparation, we found that motoneurons were organized into four pools with specific topographic locations and were incrementally recruited to produce swimming at different frequencies. The threshold of recruitment was not dictated by the input resistance of motoneurons, but was instead set by a combination of specific biophysical properties and the strength of the synaptic currents. Our results provide insights into the cellular and synaptic computations governing recruitment of motoneurons during locomotion
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Biomedizinische Optik
MPI für medizinische Forschung/Abteilung Biomedizinische Optik/Gruppe Johann Bollmann
Identifiers:LOCALID:7629
URI:http%3A%2F%2Fwww.nature.com%2Fneuro%2Fjournal%2Fv1...
URI:http%3A%2F%2Fwww.nature.com%2Fneuro%2Fjournal%2Fv1...
URI:http%3A%2F%2Fwww.nature.com%2Fneuro%2Fjournal%2Fv1...
DOI:10.1038%2Fnn.2704
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