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          Institute: MPI für medizinische Forschung     Collection: Max-Planck-Forschungsgruppe Entwicklungsgenetik des Nervensystems (Soojin Ryu)     Display Documents



ID: 569573.0, MPI für medizinische Forschung / Max-Planck-Forschungsgruppe Entwicklungsgenetik des Nervensystems (Soojin Ryu)
Orthopedia Homeodomain Protein Is Essential for Diencephalic Dopaminergic Neuron Development
Translation of Title:Orthopedia Homeodomain Protein Is Essential for Diencephalic Dopaminergic Neuron Development
Authors:Ryu, Soojin; Mahler, Julia; Acampora, Dario; Holzschuh, Jochen; Erhardt, Simone; Omodei, Daniela; Simeone, Antonio; Driever, Wolfgang
Language:English
Date of Publication (YYYY-MM-DD):2007-05-15
Title of Journal:Current Biology
Journal Abbrev.:Curr. Biol.
Volume:17
Issue / Number:10
Start Page:873
End Page:880
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Neurons that produce dopamine as a neurotransmitter constitute a heterogeneous group involved in the control of various behaviors and physiology. In mammals, dopaminergic neurons are found in distinct clusters mainly located in the ventral midbrain and the caudal forebrain [1]. Although much is known about midbrain dopaminergic neurons, development of diencephalic dopaminergic neurons is poorly understood. Here we demonstrate that Orthopedia (Otp) homeodomain protein is essential for the development of specific subsets of diencephalic dopaminergic neurons. Zebrafish embryos lacking Otp activity are devoid of dopaminergic neurons in the hypothalamus and the posterior tuberculum. Similarly, Otp−/− mouse 2 and 3 embryos lack diencephalic dopaminergic neurons of the A11 group, which constitutes the diencephalospinal dopaminergic system. In both systems, Otp is expressed in the affected dopaminergic neurons as well as in potential precursor populations, and it might contribute to dopaminergic cell specification and differentiation. In fish, overexpression of Otp can induce ectopic tyrosine hydroxylase and dopamine transporter expression, indicating that Otp can specify aspects of dopaminergic identity. Thus, Otp is one of the few known transcription factors that can determine aspects of the dopaminergic phenotype and the first known factor to control the development of the diencephalospinal dopaminergic system
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:wkaiser
Affiliations:MPI für medizinische Forschung/Max-Planck-Forschungsgruppe Entwicklungsgenetik des Nervensystems (Soojin Ryu)
Identifiers:LOCALID:7037
URI:http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob...
URI:http%3A%2F%2Fdx.doi.org%2F10.1016%2Fj.cub.2007.04....
URI:http%3A%2F%2Fzfin.org%2Fcgi-bin%2Fwebdriver%3FMIva...
DOI:10.1016%2Fj.cub.2007.04.003%20
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