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          Institute: MPI für Neurobiologie     Collection: Molecular Neurobiology     Display Documents

ID: 570365.0, MPI für Neurobiologie / Molecular Neurobiology
Presynapses in Kenyon Cell Dendrites in the Mushroom Body Calyx of Drosophila
Authors:Christiansen, F.; Zube, C.; Andlauer, T. F. M.; Wichmann, C.; Fouquet, W.; Owald, D.; Mertel, S.; Leiss, F.; Tavosanis, G.; Luna, A. J. F.; Fiala, A.; Sigrist, S. J.
Date of Publication (YYYY-MM-DD):2011-06-29
Title of Journal:Journal of Neuroscience
Journal Abbrev.:J. Neurosci.
Issue / Number:26
Start Page:9696
End Page:9707
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Plastic changes at the presynaptic sites of the mushroom body (MB) principal neurons called Kenyon cells (KCs) are considered to represent a neuronal substrate underlying olfactory learning and memory. It is generally believed that presynaptic and postsynaptic sites of KCs are spatially segregated. In the MB calyx, KCs receive olfactory input from projection neurons (PNs) on their dendrites. Their presynaptic sites, however, are thought to be restricted to the axonal projections within the MB lobes. Here, we show that KCs also form presynapses along their calycal dendrites, by using novel transgenic tools for visualizing presynaptic active zones and postsynaptic densities. At these presynapses, vesicle release following stimulation could be observed. They reside at a distance from the PN input into the KC dendrites, suggesting that regions of presynaptic and postsynaptic differentiation are segregated along individual KC dendrites. KC presynapses are present in gamma-type KCs that support short-and long-term memory in adult flies and larvae. They can also be observed in alpha/beta-type KCs, which are involved in memory retrieval, but not in alpha'/beta'-type KCs, which are implicated in memory acquisition and consolidation. We hypothesize that, as in mammals, recurrent activity loops might operate for memory retrieval in the fly olfactory system. The newly identified KC-derived presynapses in the calyx are, inter alia, candidate sites for the formation of memory traces during olfactory learning.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Affiliations:MPI für Neurobiologie/Molecular Neurobiology (Klein)/Dendrite differentiation (Tavosanis)
External Affiliations:[Christiansen, F; Zube, C; Andlauer, TFM; Wichmann, C; Fouquet, W; Owald, D; Mertel, S; Sigrist, SJ] Free Univ Berlin, Dept Genet, Inst Biol, D-14195 Berlin, Germany; [Luna, AJF; Fiala, A] Univ Gottingen, Dept Mol Neurobiol Behav, D-37077 Gottingen, Germany; [Christiansen, F; Andlauer, TFM; Wichmann, C; Fouquet, W; Owald, D; Sigrist, SJ] Charite, D-10117 Berlin, Germany; [Andlauer, TFM] Univ Wurzburg, Rudolf Virchow Ctr, Deutsch Forsch Gemeinschaft Res Ctr Expt Biomed, D-97080 Wurzburg, Germany; [Andlauer, TFM] Max Planck Inst Colloids & Interfaces, D-14424 Potsdam, Germany
Identifiers:ISI:000292189500028 [ID No:1]
ISSN:0270-6474 [ID No:2]
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