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ID: 570369.0, MPI für Neurobiologie / Behavioral Genetics
Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila
Authors:Sejourne, J.; Placais, P. Y.; Aso, Y.; Siwanowicz, I.; Trannoy, S.; Thoma, V.; Tedjakumala, S. R.; Rubin, G. M.; Tchenio, P.; Ito, K.; Isabel, G.; Tanimoto, H.; Preat, T.
Language:English
Date of Publication (YYYY-MM-DD):2011-07
Title of Journal:Nature Neuroscience
Journal Abbrev.:Nat. Neurosci.
Volume:14
Issue / Number:7
Start Page:903
End Page:910
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Aversive olfactory memory is formed in the mushroom bodies in Drosophila melanogaster. Memory retrieval requires mushroom body output, but the manner in which a memory trace in the mushroom body drives conditioned avoidance of a learned odor remains unknown. To identify neurons that are involved in olfactory memory retrieval, we performed an anatomical and functional screen of defined sets of mushroom body output neurons. We found that MB-V2 neurons were essential for retrieval of both short- and long-lasting memory, but not for memory formation or memory consolidation. MB-V2 neurons are cholinergic efferent neurons that project from the mushroom body vertical lobes to the middle superiormedial protocerebrum and the lateral horn. Notably, the odor response of MB-V2 neurons was modified after conditioning. As the lateral horn has been implicated in innate responses to repellent odorants, we propose that MB-V2 neurons recruit the olfactory pathway involved in innate odor avoidance during memory retrieval.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Annegret Cerny
Affiliations:MPI für Neurobiologie/Behavioral Genetics (Tanimoto)
External Affiliations:[Sejourne, J; Placais, PY; Trannoy, S; Tchenio, P; Isabel, G; Preat, T] Ecole Super Phys & Chim Ind Ville Paris, CNRS, Neurobiol Unit, Paris, France; [Aso, Y; Rubin, GM] Howard Hughes Med Inst, Ashburn, VA USA; [Tchenio, P] Univ Paris 11, CNRS, UPR 3321, F-91405 Orsay, France; [Ito, K] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo, Japan
Identifiers:ISI:000292081700019 [ID No:1]
ISSN:1097-6256 [ID No:2]
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