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          Institute: MPI für Dynamik komplexer technischer Systeme     Collection: Physical and Chemical Foundations of Process Engineering     Display Documents



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ID: 571886.1, MPI für Dynamik komplexer technischer Systeme / Physical and Chemical Foundations of Process Engineering
Separation of racemic bicalutamide by an optimized combination of continuous chromatography and selective crystallization
Authors:Kaemmerer, H.; Horvath, Z.; Lee, J. W.; Kaspereit, M.; Arnell, R.; Hedberg, M. H.; Herschend, B.; Jones, M. J.; Larson, K.; Lorenz, H.; Seidel-Morgenstern, A.
Language:English
Date of Publication (YYYY-MM-DD):2012
Title of Journal:Organic Process Research & Development
Volume:16
Issue / Number:2
Start Page:331
End Page:342
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:A racemic mixture of bicalutamide, a drug substance used in the treatment of prostate cancer, was separated by simulated moving bed chromatography with the objective of maximizing throughput at reduced outlet purity. The enriched extract stream was purified further by a crystallization process exploiting a shift in the eutectic composition. The optimal purity in between both process steps was identified. The separation scheme developed was validated on a scale of 600 g and the results were compared to the state-of-the art and discussed. The investigated scheme revealed a wide range of promising coupling conditions while showing superior productivities and enhanced process robustness.

Copyright © 2011 American Chemical Society [accessed October 7th 2011]
Free Keywords:Enantiomer, Bicalutamide, Chiral separation, Coupled process, Crystallization, Chromatography
External Publication Status:published
Document Type:Article
Communicated by:Andreas Seidel-Morgenstern
Affiliations:MPI für Dynamik komplexer technischer Systeme/Physical and Chemical Foundations of Process Engineering
External Affiliations:Otto-von-Guericke-Universität Magdeburg,
Institut für Verfahrenstechnik,
39106 Magdeburg, Germany

Evonik Industries AG, 63457 Hanau, Germany

AstraZeneca R&D Södertälje,
Pharmaceutical Development, 15185 Södertälje, Sweden
Identifiers:URL:http://dx.doi.org/10.1021/op200136z
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