Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für Dynamik komplexer technischer Systeme     Collection: Physical and Chemical Foundations of Process Engineering     Display Documents



  history
ID: 572823.1, MPI für Dynamik komplexer technischer Systeme / Physical and Chemical Foundations of Process Engineering
Design of an Integrated Process of Chromatography, Crystallization and Racemization for the Resolution of 2',6'-Pipecoloxylidide (PPX)
Authors:von Langermann, J.; Kaspereit, M.; Shakeri, M.; Lorenz, H.; Hedberg, M. H.; Jones, M. J.; Larson, K.; Herschend, B.; Arnell, R.; Temmel, E.; Bäckvall, J.-E.; Kienle, A.; Seidel-Morgenstern, A.
Language:English
Date of Publication (YYYY-MM-DD):2012
Title of Journal:Organic Process Research & Development
Volume:16
Issue / Number:2
Start Page:343
End Page:352
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:An integrated process for the chiral separation of the industrially relevant substance 2′,6′-pipecoloxylidide (PPX), an intermediate in the manufacture of a number of anesthetics, was developed. By combining three different techniques, chromatography, crystallization, and racemization, high productivity was achieved. All unit operations were executed using a common solvent system, full recycling, and a minimum of solvent exchanges or removals. The target molecule was obtained with an enantiopurity of >99.5 wt %.
External Publication Status:published
Document Type:Article
Communicated by:Andreas Seidel-Morgenstern
Affiliations:MPI für Dynamik komplexer technischer Systeme/Physical and Chemical Foundations of Process Engineering
MPI für Dynamik komplexer technischer Systeme/Process Synthesis and Process Dynamics
MPI für Dynamik komplexer technischer Systeme/International Max Planck Research School (IMPRS)
External Affiliations:Friedrich-Alexander University Erlangen-Nuernberg, Department for Separation Science and Technology,
Erlangen, Germany

Stockholm University,
Department of Organic Chemistry,
Arrhenius Laboratory,
Stockholm, Sweden

AstraZeneca AB,
Pharmaceutical Development,
Medicines Development,
Södertälje, Sweden

Otto-von-Guericke-Universität
Institut für Verfahrenstechnik,
Magdeburg, Germany

Otto-von-Guericke-Universität
Institut für Automatisierungstechnik,
Magdeburg, Germany
Identifiers:URL:http://dx.doi.org/10.1021/op200268h
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.