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          Institute: MPI für Evolutionsbiologie     Collection: Evolutionary genetics     Display Documents



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ID: 573387.0, MPI für Evolutionsbiologie / Evolutionary genetics
A comparative assessment of mandible shape in a consomic strain panel of the house mouse (Mus musculus) - implications for epistasis and evolvability of quantitative traits
Authors:Boell, Louis; Gregorova, Sona; Forejt, Jiri; Tautz, Diethard
Language:English
Date of Publication (YYYY-MM-DD):2011-12
Title of Journal:BMC Evolutionary Biology
Volume:11
Issue / Number:1
Sequence Number of Article:309
Review Status:not specified
Audience:Not Specified
Abstract / Description:Background
Expectations of repeatedly finding associations between given genes and phenotypes have been borne out by studies of parallel evolution, especially for traits involving absence or presence of characters. However, it has rarely been asked whether the genetic basis of quantitative trait variation is conserved at the intra- or even at the interspecific level. This question is especially relevant for shape, where the high dimensionality of variation seems to require a highly complex genetic architecture involving many genes.
Results
We analyse here the genetic effects of chromosome substitution strains carrying M. m. musculus chromosomes in a largely M. m. domesticus background on mandible shape and compare them to the results of previously published QTL mapping data between M. m. domesticus strains. We find that the distribution of genetic effects and effect sizes across the genome is consistent between the studies, while the specific shape changes associated with the chromosomes are different. We find also that the sum of the effects from the different M. m. musculus chromosomes is very different from the shape of the strain from which they were derived, as well as all known wild type shapes.
Conclusions
Our results suggest that the relative chromosome-wide effect sizes are comparable between the long separated subspecies M. m. domesticus and M. m. musculus, hinting at a relative stability of genes involved in this complex trait. However, the absolute effect sizes and the effect directions may be allele-dependent, or are context dependent, i.e. epistatic interactions appear to play an important role in controlling shape.
External Publication Status:published
Document Type:Article
Communicated by:Brigitte Lechner
Affiliations:MPI für Evolutionsbiologie/Abt. Evolutionsgenetik
External Affiliations:2Institute of Molecular Genetics, Academy of Sciences
of the Czech Republic, 14220 Prague, Czech Republic
Identifiers:ISSN:1471-2148 [ID-No:1]
DOI:10.1186/1471-2148-11-309 [ID-No:2]
LOCALID:2878/S 39222 [Listen-Nummer/S-Nummer]
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