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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2011-arch     Display Documents



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ID: 585163.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2011-arch
Shotgun lipidomics on high resolution mass spectrometers.
Authors:Schwudke, Dominik; Schuhmann, Kai; Herzog, Ronny; Bornstein, Stefan R.; Shevchenko, Andrej
Date of Publication (YYYY-MM-DD):2011
Title of Journal:Cold Spring Harbor Perspectives in Biology
Volume:3
Issue / Number:9
Sequence Number of Article:a004614
Copyright:not available
Review Status:not specified
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Despite their compositional complexity, lipidomes comprise a large number of isobaric species that cannot be distinguished by conventional low resolution mass spectrometry and therefore in-depth MS/MS analysis was required for their accurate quantification. Here we argue that the progress in high resolution mass spectrometry is changing the concept of lipidome characterization. Because exact masses of isobaric species belonging to different lipid classes are not necessarily identical, they can now be distinguished and directly quantified in total lipid extracts. By streamlining and simplifying the molecular characterization of lipidomes, high resolution mass spectrometry has developed into a generic tool for cell biology and molecular medicine.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:thuem
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:4686
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