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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2011-arch     Display Documents



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ID: 585183.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2011-arch
Altered desaturation and elongation of fatty acids in hormone-sensitive lipase null mice.
Authors:Fernandez, Céline; Schuhmann, Kai; Herzog, Ronny; Fielding, Barbara; Frayn, Keith; Shevchenko, Andrej; James, Peter; Holm, Cecilia; Ström, Kristoffer
Date of Publication (YYYY-MM-DD):2011
Title of Journal:PLoS ONE
Volume:6
Issue / Number:6
Sequence Number of Article:e21603
Copyright:not available
Review Status:not specified
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Hormone-sensitive lipase (HSL) is expressed predominantly in adipose tissue, where it plays an important role in catecholamine-stimulated hydrolysis of stored lipids, thus mobilizing fatty acids. HSL exhibits broad substrate specificity and besides acylglycerides it hydrolyzes cholesteryl esters, retinyl esters and lipoidal esters. Despite its role in fatty acid mobilization, HSL null mice have been shown to be resistant to diet-induced obesity. The aim of this study was to define lipid profiles in plasma, white adipose tissue (WAT) and liver of HSL null mice, in order to better understand the role of this multifunctional enzyme.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:thuem
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:4689
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