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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2011-arch     Display Documents



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ID: 585264.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2011-arch
Proliferating versus differentiating stem and cancer cells exhibit distinct midbody-release behaviour.
Authors:Ettinger, Andreas; Wilsch-Bräuninger, Michaela; Marzesco, Anne-Marie; Bickle, Marc; Lohmann, Annett; Maliga, Zoltan; Karbanová, Jana; Corbeil, Denis; Hyman, Anthony A.; Huttner, Wieland B.
Date of Publication (YYYY-MM-DD):2011
Title of Journal:Nature Communications
Volume:2
Sequence Number of Article:503
Copyright:not available
Review Status:not specified
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The central portion of the midbody, a cytoplasmic bridge between nascent daughter cells at the end of cell division, has generally been thought to be retained by one of the daughter cells, but has, recently, also been shown to be released into the extracellular space. The significance of midbody-retention versus -release is unknown. Here we show, by quantitatively analysing midbody-fate in various cell lines under different growth conditions, that the extent of midbody-release is significantly greater in stem cells than cancer-derived cells. Induction of cell differentiation is accompanied by an increase in midbody-release. Knockdown of the endosomal sorting complex required for transport family members, Alix and tumour-suppressor gene 101, or of their interaction partner, centrosomal protein 55, impairs midbody-release, suggesting mechanistic similarities to abscission. Cells with such impaired midbody-release exhibit enhanced responsiveness to a differentiation stimulus. Taken together, midbody-release emerges as a characteristic feature of cells capable of differentiation.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:thuem
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:4616
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