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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 1 - Protein Evolution (A. Lupas)     Display Documents



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ID: 591414.0, MPI für Entwicklungsbiologie / Abteilung 1 - Protein Evolution (A. Lupas)
The sequence of the pYV virulence plasmid from Yersinia enterocolitica strain WA-314 biogroup 1B serotype O:8
Authors:Oberhettinger, P.; Schutz, M.; Raddatz, G.; Keller, H.; Autenrieth, I. B.; Linke, D.
Date of Publication (YYYY-MM-DD):2011-01
Title of Journal:Plasmid
Volume:65
Issue / Number:1
Start Page:20
End Page:24
Review Status:not specified
Audience:Not Specified
Abstract / Description:Our laboratory strain Yersinia enterocolitica strain WA-314 biogroup 1B serotype O:8 displayed a different adhesion behavior to host cells compared to other Yersinia strains. To investigate whether this is based on differences in the gene content of the large pYV virulence plasmid which contains the major Yersinia adhesin YadA, we set out to sequence pYV(WA-314). pYV(WA-314) is very similar to pYV127/90, with a notable difference in the length of the Type III secretion system component YscP, which determines the needle length of the system. We found that we could improve the annotation of proteins previously described as "hypothetical" in pYV127/90 and other pYV plasmids, and show that pYV plasmids contain several and seemingly redundant plasmid partitioning and stabilization systems, explaining why these plasmids are not easily lost in laboratory cultures of Yersinia strains.
Free Keywords:Amino Acid Sequence; Bacterial Proteins/chemistry; Base Sequence; DNA Replication/genetics; Molecular Sequence Annotation; Molecular Sequence Data; Physical Chromosome Mapping; Plasmids/*genetics; Serotyping; Virulence/genetics; Yersinia enterocolitica/classification/*genetics/*pathogenicity
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 1 - Proteinevolution (Andrei Lupas)
External Affiliations:%G eng
Identifiers:ISSN:1095-9890 (Electronic) 0147-619X (Linking) %R S014... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/20875451 [ID No:2]
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