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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 6 - Molecular Biology (D. Weigel)     Display Documents



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ID: 591478.0, MPI für Entwicklungsbiologie / Abteilung 6 - Molecular Biology (D. Weigel)
The Arabidopsis lyrata genome sequence and the basis of rapid genome size change
Authors:Hu, T. T.; Pattyn, P.; Bakker, E. G.; Cao, J.; Cheng, J. F.; Clark, R. M.; Fahlgren, N.; Fawcett, J. A.; Grimwood, J.; Gundlach, H.; Haberer, G.; Hollister, J. D.; Ossowski, S.; Ottilar, R. P.; Salamov, A. A.; Schneeberger, K.; Spannagl, M.; Wang, X.; Yang, L.; Nasrallah, M. E.; Bergelson, J.; Carrington, J. C.; Gaut, B. S.; Schmutz, J.; Mayer, K. F.; Van de Peer, Y.; Grigoriev, I. V.; Nordborg, M.; Weigel, D.; Guo, Y. L.
Date of Publication (YYYY-MM-DD):2011-05
Title of Journal:Nat. Genet.
Volume:43
Issue / Number:5
Start Page:476
End Page:481
Review Status:not specified
Audience:Not Specified
Abstract / Description:We report the 207-Mb genome sequence of the North American Arabidopsis lyrata strain MN47 based on 8.3x dideoxy sequence coverage. We predict 32,670 genes in this outcrossing species compared to the 27,025 genes in the selfing species Arabidopsis thaliana. The much smaller 125-Mb genome of A. thaliana, which diverged from A. lyrata 10 million years ago, likely constitutes the derived state for the family. We found evidence for DNA loss from large-scale rearrangements, but most of the difference in genome size can be attributed to hundreds of thousands of small deletions, mostly in noncoding DNA and transposons. Analysis of deletions and insertions still segregating in A. thaliana indicates that the process of DNA loss is ongoing, suggesting pervasive selection for a smaller genome. The high-quality reference genome sequence for A. lyrata will be an important resource for functional, evolutionary and ecological studies in the genus Arabidopsis.
Free Keywords:Arabidopsis/classification/*genetics; Base Sequence; Centromere/genetics; Chromosomes, Plant/genetics; DNA, Plant/genetics; Evolution, Molecular; *Genome, Plant; Models, Genetic; Molecular Sequence Data; Sequence Homology, Nucleic Acid; Species Specificity
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 6 - Molekulare Biologie (Detlef Weigel)
External Affiliations:%G eng
Identifiers:ISSN:1546-1718 (Electronic) 1061-4036 (Linking) %R ng.8... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/21478890 [ID No:2]
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